A15 Sandra Hake
Role of mammalian histone variants H3.3 and H2A.Z in differentiation and disease
The main aim is to discover and functionally dissect the molecular mechanisms during differentiation and disease development of:
A) DAXX-dependent H3.3-mediated silencing of heterochromatic genes and the chaperone dependence of H3.3K27M in tumor development, and
B) the PWWP2A-interactome with a functional focus on the novel “core NuRD” and the proposed PHF14-RAI1-TCF20-HMG20A (PRTH) complexes in transcriptional regulation of PWWP2A-bound H2A.Z target genes.
| Name | Sandra Hake |
|---|---|
| Telephone | +49-641-99-35460 |