Winter School 2017
Program of the 2017 IRTG Winter School
7th Winter School of the Collaborative Research Centre TRR81
“Chromatin Changes in Differentiation and Malignancies” Marburg-Giessen-Bad Nauheim-Rotterdam
at the Kleinwalsertal, February 26 - March 03, 2017
Sunday 26.2.2017
20:15 Ski Rental
Monday 27.2.2017
MORNING SESSION
09:00-11:30
Chair: Ruben Boers and Sara Völkel
Welcome at the seminar room - Sjaak Philipsen
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Mingjing Li (PI Braun BN) Epigenetic regulation of cardiomyocyte proliferation and cardiac regeneration
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Ilias Boltsis (PIs Grosveld & Gribnau R) The role of non-coding RNAs and transcription factor networks in X-inactivation
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Peeyush Sahu (PI Bauer M) Effects of PRMT6 deletion on H3R2me2a deposition and transcription in NT2/D1 cells
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Martijn Vos (PI Grosveld & Delwel R) Targeting G protein coupled receptor 56 using (ant)agonistic antibodies, a potential therapeutic in acute myeloid leukemia
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Markus Seibert (PI Schmitz G) Characterization of histone H2B serine 6 phosphorylation
- Lize Meert (PI Poot R) Protein interaction networks of autism chromatin modifiers in human neural stem cells
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Ilona Vuist and Karim Bouazoune
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Hegias Mira Bontenbal (PI Gribnau R) Generation of an X Chromosome Reactivation mouse model
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Sandra Hake (new PI) Histone variants in stem cell differentiation and disease
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Anne Korporaal (PI Philipsen R) The Klf1 Nan variant affects developmental expression patterns of globin genes
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Katja Sträßer / Wolfgang Wende (new PI) Coupling between nuclear mRNP formation and epigenetic marks
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Aleksandra Turkiewicz (PI Borggrefe G) Characterization of the RBP-J/SHARP-mediated repression mechanism at Notch target genes
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Soni Pullamsetti (new PI) JMJD histone demethylases: Role and regulation in the pathogenesis of Pulmonary Hypertension
Tuesday 28.2.2017
08:00-09:00 Breakfast
MORNING SESSION
09:00-11:30
Chair: Hegias Mira Bontenbal and Parysatis Sachs
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Valentina Casa (PI Wendt R) Regulation of the cohesin-loading factor NIPBL: role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element
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Fan Wu (PI Braun BN) Tet3 mediated epigenetic signature affects cell identity and remodeling in lung bronchioles
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Jeffrey Boeren (PI Gribnau R) Characterization of the Xist promoter protein interactors by CasID
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Francesca Ferrante (PI Borggrefe G) HDAC3 is a positive regulator of Notch signalling that acts by stabilizing the cleaved Notch protein
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Judith Birkhoff (PI Huylebroeck R) Transcription factor Zeb2 action mechanisms and regulations in embryonic cell fate decisions
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Karim Bouazoune (PI Brehm M) Biochemical characterization of the DNA repair protein SHPRH using nucleosome substrates
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Laura Brueckner and Markus Seibert
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Peter Kolb (new PI) Identifying selective protein ligands in chemical space
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Ilona Vuist (PI Houtsmuller R) Effects of UV induced DNA damage on mRNA concentration in single genes
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Wibke Diederich (new PI) Computer-based Design and synthesis of Protein Arginine Methyltransferase 4 inhibitors
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Ayestha Sijm (PI Verrijzer R) Gene control by USP7/GMPS
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Debbie van den Berg (new PI) Migration matters: Transcriptional control of forebrain development by Nipbl and Zfp609
Wednesday 1.3.2017
Morning SESSION
9:00-11:30
Chair: Andrea Conidi and Aleksandra Turkiewicz
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Joanna Brühl (PI Brehm M) Identification of potential chromatin remodeling factor drug targets in Acute Myeloid Leukemia
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Lennart van der Wal (PIs Demmers and Verrijzer R) Analyzing changes in ubiquitylation status using quantitative mass spectrometry
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Ikram Ullah (PI Brehm M) dMi-2 and RNA, EcR/USP
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Marti Quevedo (PI Poot R) A Mediator-associated transcription factor activates transcription in neural stem cells
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Parysatis Sachs (PI Mermoud M) Genome-wide mapping of the ATP-dependent chromatin remodeler SMARCAD1 in mouse embryonic stem cells
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Laura Brueckner (PI Van Steensel A) Studying the interplay between genome organization and gene regulation by thousands of integrated reporters
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Valentina Casa and Peeyush Sahu
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Ruben Schep (PI Van Steensel A) What are the effects of chromatin on DNA double strand break repair response?
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Mehrnaz Ghazvini (PI Gribnau R) Study of XCI regulation in development in human
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Jana Haas (PI Schmitz G) Analysis of HIPK2-mediated chromatin decondensation
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Esther Sleddens-Linkels (PI Baarends R) Meiotic checkpoint activation in men with non -obstructive azoospermia
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Tim Hundertmark (PI Renkawitz-Pohl M) The role of Plus3 domain proteins in male germ cell development of Drosophila
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Andrea Conidi (PI Huylebroeck R) How sweet is Zeb2: O-GlcNAcylation of Zeb2 is necessary for its activity as cell-autonomous E-cadherin (Cdh1) regulator and BMP signalling antagonist
Thursday 2.3.2017
08:00-09:00 Breakfast
MORNING SESSION
09:00-11:30
Chair: Marti Quevedo and Jana Haas
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Dong Ding (PI Mermoud M) Study of SMARCAD1 Function in Mouse Embryonic Stem Cells by Proteomics and RNAi
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Joachim Boers (PI Gribnau R) MeD-seq, a novel method to detect genome wide DNA methylation – Bioinformatics
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Ruben Boers (PI Gribnau R) MeD-seq, a novel method to detect genome wide DNA methylation – Wet lab
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Sara Völkel (PI Suske M) Zinc finger independent genome-wide binding of Sp2 to CCAAT box promoters
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Teresa Robert Finestra (PI Gribnau R) Single-cell methylation profiling using MeD-seq
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Sjaak Philipsen Closing remarks
12:00-16:00 Open Discussions
16:00-17:30 Workshops on Perspectives
17:30-18:30 Farewell Dinner and events:
19:00-20:00 Torch-light procession
20:00-late Farewell party
Friday 3.3.2017
Download the program in PDF format here!