A12 Tilman Borggrefe
Chromatin regulation mediated by the RBP-J/SHARP corepressor complex
The Notch pathway is a highly conserved cell-to-cell signaling mechanism that ultimately results in changes in gene expression. In the absence of a Notch signal, the transcription factor RBPJ together with its cofactor SHARP actively represses Notch target genes by recruiting the NCoR/HDAC-complex. Based on the crystal structure of the RBPJ/SHARP-complex and CRISPR/Cas9-mediated knockouts we will analyze the repressive chromatin-based mechanism utilizing genomewide approaches. Furthermore, we will screen for small-molecules that disrupt the SHARP-repressive function. The project may help to discover novel therapeutic targets for Notch-associated diseases.
| Name | Tilman Borggrefe |
|---|---|
| Tilman.Borggrefe@biochemie.med.uni-giessen.de | |
| Telephone | +49-(0)641-9947400 |