Pulmonary Hypertension and Right Heart Insufficiency
Pulmonary Hypertension (PH) is caused by pulmonary vascular remodelling leading to right heart overload.
Mitochondrial alterations play a major role in metabolic reprogramming of vascular cells promoting PH.
We identified the role of mitochondrial reactive oxygen species (ROS) in hypoxia-induced PH and right heart remodelling.
This project focusses on the role of mitochondrial ROS in different forms of PH and right heart remodelling.