Cell Biology (B)
Project part B (cell biology) has eight projects with cell biological (B1, B2, B4 – B7) and clinical focus (B8, B9) with imaging technologies. TRR 79 seeks to generate aetiology-adapted materials and therefore these projects evaluate the local tissue situation after destruction of the bony integrity in tumour (B1) and osteporosis patients (B2).
Project B1
Bone destruction in multiple myeloma: pathogenesis and model as basis for therapeutic targeting by of bone substance defects by etiology-based bone substitute material
Project B4
Influence of multiphase bone replacement materials and surface-modified titanium alloys on the differentiation of osteoblasts/MSC
Project B 5
Modification of cell-cell- and cell-matrix-communication within bone tissue by new materials
Project B6 (completed)
The influence of bone substitute biomaterial on angiogenesis applied at bone defects caused by benign and malignant diseases
Project B7
Influence of aetiology-adapted bone substitutes on the regulation of bone remodeling, microvascularisation and innervation in systemically diseased bone
Project B8
Investigation of bone defects and microcirculation with volume computed tomography and dynamic contrast-enhanced magnetic resonance imaging
Project B9
Quantitative studies of metabolism (F-18-deoxyglucose) and bone metabolism (F-18-fluoride) with dynamic positron emission tomography-computed tomography (dPET-CT)
Project B10 (new)
Cellular differences in sensitivity against drug releasing bone substitute materials within physiological and pathological bone remodeling
Project B11 (new)
Structural and cell-biological investigations for characterization of the bone-bone marrow interface
Project B12 (new)
Molecular characterization of interactions between bone-substitute material and surrounding tissue in sheep, rat, and myeloma-mouse-model by transcriptome profiling using next generation RNA-Sequencing and functional validation