Publications Prof. Dr. Michael Kracht

2024

• Jurida L, Werner S, Knapp F, Niemann B, Li L, Grün D, Wirth S, Weber A, Beuerlein K, Liebetrau C, Wiedenroth C, Guth S, Kojonazarov B, Jafari L, Weissmann N, Günther S, Braun T, Bartkuhn M, Schermuly R, Dorfmüller P, Yin X, Mayr M, Schmitz ML, Czech L, Schlüter K, Schulz R, Rohrbach S, Kracht M. A common gene signature of the right ventricle in failing rat and human hearts. Nat Cardiovasc Res (2024) 3, 819–840. https://doi.org/10.1038/s44161-024-00485-1.

• Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S. Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat. Basic Res Cardiol. 2024 Aug; 119(4):587-611. doi: 10.1007/s00395-024-01051-3.

2023

• Belapurkar R, Pfisterer M, Dreute J, Werner S, Zukunft S, Fleming I, Kracht M, Schmitz ML. A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress. Cell Death Dis. 2023 Jul 27;14(7):477.

• Liu L, Madhugiri R, Saul VV, Bacher S, Kracht M, Pleschka S, Schmitz ML. Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5'-termini of RNA and polymerase function. Sci Rep. 2023 Apr 29;13(1):7042.

• Priester J, Meier-Soelch J, Weiser H, Heylmann D, Weber A, Linne U, Kracht M. Metabolic labeling and LC-MS/MS-based identification of interleukin-1α-induced secreted proteomes from epithelial cells in the presence or absence of serum. STAR Protoc. 2023 Mar 31;4(2):102195. doi: 10.1016/j.xpro.2023.102195. Online ahead of print.

• Liu L, Weber A, Linne U, Shehata M, Pleschka S, Kracht M, Schmitz L. Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex. mBio. 2023 January/February 2023 Volume 14 Issue 1.

2022

• Shaban MS, Müller C, Mayr-Buro C, Weiser H, Schmitz ML, Ziebuhr J, Kracht M. Reply to: The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein. Nat Commun. 2022 Nov 14;13(1):6550.

• Priester J, Dreute J, Kracht M, Schmitz ML. Post-Transcriptional Control of mRNA Metabolism and Protein Secretion: The Third Level of Regulation within the NF-κB System. Biomedicines. 2022 Aug 29;10(9):2108.

• Mansouri S, Heylmann D, Stiewe T, Kracht M, Savai R. Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity. Elife. 2022 Sep 8;11:e79895.

• Shaban MS, Mayr-Buro C, Meier-Soelch J, Albert BV, Schmitz ML, Ziebuhr J, Kracht M. Thapsigargin: key to new host-directed coronavirus antivirals? Trends Pharmacol Sci. 2022 Jul;43(7):557-568.

• Schmitz ML, Dreute J, Pfisterer M, Günther S, Kracht M, Chillappagari S. SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression. Heliyon. 2022 Mar 1;8(3):e09029.

2021

• Meier-Sölch J, Mayr-Buro C, Juli J, Leib L, Linne U, Dreute J, Papantonis A, Schmitz ML, Kracht M. Monitoring the Levels of Cellular NF-κB Activation States. Cancers 2021, 13(21), 5351.

• Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M. Multi-level inhibition of coronavirus replication by chemical ER stress. Nat Commun. 2021, 12. 5536.

• Bacher S, Stekman H, Farah CM, Karger A, Kracht M, Schmitz ML. MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival. Mol Cell Biol. 2021 Sep 24;41(10):e0008121.

• Busch J, Moreno R, de la Vega L, Saul VV, Bacher S, von Zweydorf F, Ueffing M, Weber A, Gloeckner CJ, Linne U, Kracht M, Schmitz ML. TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks. Cancers (Basel). 2021 Jul 19;13(14):3618.

• Bacher S, Meier-Soelch J, Kracht M, Schmitz ML. Regulation of Transcription Factor NF-κB in Its Natural Habitat: The Nucleus. Cells. 2021 Mar 29;10(4):753.

• Chelladurai P, Boucherat O, Stenmark K, Kracht M, Seeger W, Bauer UM, Bonnet S, Pullamsetti SS. Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy. Br J Pharmacol. 2021 Jan;178(1):54-71.

2020

• Knapp F, Niemann B, Li L, Molenda N, Kracht M, Schulz R, Rohrbach S. Differential effects of right and left heart failure on skeletal muscle in rats. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1830-1849.

• Haas J, Bloesel D, Bacher S, Kracht M, Schmitz ML. Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation. Front Cell Dev Biol. 2020 Sep 1;8:852.

• Kracht M, Müller-Ladner U, Schmitz ML. Mutual regulation of metabolic processes and proinflammatory NF-kB signaling. J Allergy Clin Immunol. 2020 Oct;146(4):694-705.

• Niemann B, Li L, Siegler D, Siegler BH, Knapp F, Hanna J, Aslam M, Kracht M, Schulz R, Rohrbach S. CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response. Cells. 2020 May 15;9(5):1229.

• Zarnack K, Balasubramanian S, Gantier MP, Kunetsky V, Kracht M, Schmitz ML, Sträßer K. Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules. 2020 Sep 11;10(9):1310.

• Kracht M., Holtmann H. (2020) Cytokines. In: Offermanns S., Rosenthal W. (eds) Encyclopedia of Molecular Pharmacology. 3rd ed. 2021 Springer International Publishing (Verlag) 978-3-030-57400-0 (ISBN)

• Ferrante F, Giaimo BD, Bartkuhn M, Zimmermann T, Close V, Mertens D, Nist A, Stiewe T, Meier-Soelch J, Kracht M, Just S, Klöble P, Oswald F, Borggrefe T. HDAC3 functions as a positive regulator in Notch signal transduction. Nucleic Acids Res. 2020 Apr 17;48(7):3496-3512.

• Chillappagari S, Belapurkar R, Möller A, Molenda N, Kracht M, Rohrbach S, Schmitz ML. SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism. Sci Rep. 2020 Feb 10;10(1):2268.

• Weiterer SS, Meier-Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, Brant L, Mayr-Buro C, Jurida L, Beuerlein K, Müller H, Weber A, Tenekeci U, Dittrich-Breiholz O, Bartkuhn M, Nist A, Stiewe T, van IJcken WF, Riedlinger T, Schmitz ML, Papantonis A, Kracht M. Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J. 2020 Jan 2;39(1):e101533.

2019

• Saul VV, Seibert M, Kruger M, Jeratsch S, Kracht M, Schmitz ML. ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation. iScience. 2019;19:527-44.

• Mayr-Buro C, Schlereth E, Beuerlein K, Tenekeci U, Meier-Soelch J, Schmitz ML, Kracht M. Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays. Cancers (Basel). 2019 Aug 16;11(8).

• Riedlinger T, Bartkuhn M, Zimmermann T, Hake SB, Nist A, Stiewe T, Kracht M, Schmitz ML. Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression. Cancers (Basel). 2019 Jun 25;11(6).

• Weber A, Dam S, Saul VV, Kuznetsova I, Müller C, Fritz-Wolf K, Becker K, Linne U,  Gu H,  Stokes MP, Pleschka S, Kracht M, Schmitz ML. Phosphoproteome analysis of cells infected with adapted and non-adapted influenza A virus reveals novel pro- and antiviral signaling networks. J Virol. 2019 Jun 14;93(13).

• Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML. CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol. 2019 Apr 1;218(4):1164-1181.

• Riedlinger T, Liefke R, Meier-Soelch J, Jurida L, Nist A, Stiewe T, Kracht M, Schmitz ML. NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression. FASEB J. 2019 Mar;33(3):4188-4202.

2018

• Schmitz ML, Shaban MS, Albert BV, Gökçen A, Kracht M. The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection. Biomedicines. 2018, 6, 58. Review.

• Meier-Soelch J, Jurida L, Weber A, Newel D, Kim J, Braun T, Schmitz ML, and Kracht M. RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol. 2018 Apr 27;9:775.

• Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK, Acker T. PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα. Cancer Res. 2018 Apr 1;78(7):1805-1819.

• Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML. The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice. Biomedicines. 2018 Mar 19;6(1).

2017

• Hagenbucher J, Stekman H, Rodriguez-Gil A, Kracht M, and Schmitz ML. Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases. Methods Mol Biol. 2017, 1510, 297-312.

• Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Köster M, May T, Schulz TF, Hauser H, Wirth D. Proliferation status defines functional properties of endothelial cells. Cell Mol Life Sci. 2017 Apr;74(7):1319-1333.

• Poppe M, Wittig S, Jurida L, Bartkuhn M, Wilhelm J, Müller H, Beuerlein K, Karl N, Bhuju S, Ziebuhr J, Schmitz ML, Kracht M. The NF-κB-dependent and – independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog. 2017 Mar 29;13(3):e1006286.
  

• Rodriguez-Gil, A., Ritter, O, Saul, VV, Wilhelm, J, Yang, CY, Grosschedl, R, Imai, Y, Kuba, K, Kracht, M, and Schmitz, ML. The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Sci . 2017, Rep 7, 3547.

• Stauber, M, Weidemann, M, Dittrich-Breiholz, O, Lobschat, K, Alten, L, Mai, M, Beckers, A, Kracht, M, and Gossler, A. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017, 423, 170-188.

2016

• Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M, Holtmann H. IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA. J Biol Chem. 2016 Nov 18;291(47):24801.

• Dam S, Kracht M, Pleschka S, Schmitz ML. The influenza A virus genotype determines the anti-viral function of NF-κB. J Virol. 2016 Aug 12;90(17):7980-90.

• Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen Z J, Busch J, Schmitz ML, Kracht M. K63-ubiquitylation and TRAF6 pathways regulate mammalian P-body formation and mRNA decapping. Mol Cell. 2016, Jun 16;62(6):943-57.

• Rodriguez-Gil A, Ritter O, Hornung J, Stekman H, Krüger M, Braun T, Kremmer E, Kracht M, Schmitz ML. HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell. 2016 Jun 15;27(12):1969-80.

• Schmitz L M, Kracht M. Cyclin dependent kinases as coregulators of inflammatory gene expression. Trends Pharmacol Sci. 2016, Feb;37(2):101-13.

2015

• Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M. The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.
  Cell Rep. 2015, Feb.10(5):726–739.

• Nerlich A, Ruangkiattikul N, Laarmann K, Janze N, Dittrich-Breiholz O, Kracht M, Goethe R. C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages. Biochim Biophys Acta. 2015, Aug;1849(8):966-78.

2014

• Schmitz ML, Kracht M, Saul VV. The intricate interplay between RNA viruses and NF-κB. Biochim Biophys Acta. 2014 Nov;1843(11):2754-2764.

• Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E. Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. Gastroenterology. 2014 Jul;147(1):184-195.e3.

• Günther J, Vogt N, Hampel K, Bikker R, Page S, Müller B, Kandemir J, Kracht M, Dittrich-Breiholz O, Huber R, Brand K. Identification of two forms of TNF tolerance in human monocytes: differential inhibition of NF-κB/AP-1- and PP1-associated signaling.
  J Immunol. 2014 Apr 1;192(7):3143-55.

• Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Kracht M, Nakagama H, Okamoto K. MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. Cancer Sci. 2014 Apr;105(4):425-30.

• Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M. Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression. Mol Cell. 2014 Jan 23;53(2):193-208.

• Milanovic M, Kracht M, Schmitz ML. The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation. Biochem J. 2014 Feb 1;457(3):401-13.

2013

• Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T. Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell Death Dis. 2013 Oct 24;4:e879.

• Dhamija S, Winzen R, Doerrie A, Behrens G, Kuehne N, Schauerte C, Neumann E, Dittrich-Breiholz O, Kracht M, Holtmann H. Interleukin-17 (IL-17) and IL-1 Activate Translation of Overlapping Sets of mRNAs, Including That of the Negative Regulator of Inflammation, MCPIP1. J Biol Chem. 2013 Jun 28;288(26):19250-9.

• Stockert J, Wolf A, Kaddatz K, Schnitzer E, Finkernagel F, Meissner W, Müller-Brüsselbach S, Kracht M, Müller R. Regulation of TAK1/TAB1-Mediated IL-1β Signaling by Cytoplasmic PPARβ/δ. PLoS One. 2013, Vol. 8, Issue 4, e63011.

• Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Hippenstiel S, Kracht M, Püschel G. (2012). NF-κB-dependent IL-8 induction by prostaglandin E2 receptors EP1 and EP4. Br J Pharmacol. 2013 Feb;168(3):704-17.

• Rehren F, Ritter B, Dittrich-Breiholz O, Henke A, Lam E, Kati S, Kracht M, Heim A. Induction of a broad spectrum of inflammation-related genes by Coxsackievirus B3 requires Interleukin-1 signaling. Med Microbiol Immunol. 2013 Feb;202(1):11-23, Epub 1212.

• Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida J, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M. (2012). The coactivator role of HDAC3 in IL-1-signaling depends on HDAC3-mediated deacetylation of p65 NF-κB. Nucleic Acids Research. 2013 Jan7:41(1):90-109, Epub 2012.

• Hansen B, Dittrich-Breiholz O, Kracht M, Windheim M. Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor. Cell Signal. 2013 Jan;25(1):214-28.

• van den Brand BT, Vermeij EA, Waterborg CE, Arntz OJ, Kracht M, Bennink MB, van den Berg WB, van de Loo FA. Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis. PLoS One. 2013;8(2):e55356.

• Haas DA, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF. The inflammatory kinase MAP 4K4 promotes reactivation of Kaposi's Sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS One. 2013;9(11):e1003737.

2012

• Buss H, Jurrmann N, Pekkonen P, Beuerlein K, Müller H, Handschick K, Wait R, Saklatvala J, Ojala PM, Schmitz ML, Naumann M, Kracht M. Cyclin-dependent kinase 6 phosphorylates NF-ĸB p65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS One. 2012 Dec26;7(12):e51847.

• Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Hävemeier A, Yakushko Y, Vikram Singh V, Dittrich-Breiholz O, Kracht M, Schulz TF. Kaposi´s Sarcoma Herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression. PLoS Pathog. 2012 Sep;8(9):e1002927.

• Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E. Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination. Oncogene. 2012 Feb 2;31(5):611-23.

• Zeitvogel J, Dalpke A, Eiz-Vesper B, Kracht M, Dittrich-Breiholz O, Werfel T, Wittmann M. Human primary keratinocytes show a restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 compared to autologous macrophages. J Biol Chem. 2012 Mar 23;287(13):9923-30.

• Kasraie S, Niebuhr M, Kopfnagel V, Dittrich-Breiholz O, Kracht M, Werfel T. Macrophages from patients with atopic dermatitis show a reduced CXCL10 expression in response to staphylococcal α-toxin. Allergy. 2012 Jan;67(1):41-9.

2011

• Wolf A, Beuerlein K, Eckart C, Weiser H, Dickkopf B, Müller H, Sakurai H, Kracht M. Identification and Functional Characterization of Novel Phosphorylation Sites in TAK1-Binding Protein (TAB) 1. PLoS One. 2011;6(12):e29256.

• Rzeczkowski K, Beuerlein K, Müller H, Dittrich-Breiholz O, Schneider H, Kettner-Buhrow D, Holtmann H, Kracht M. c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies. J Cell Biol. 2011 Aug 22;194(4):581-96.

• Mayer BA, Rehberg M, Erhardt A, Wolf A, Reichel CA, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar AM, Fürst R. Inhibitor of apoptosis proteins as novel targets in inflammatory processes. Arterioscler Thromb Vasc Biol. 2011Oct;31(10):2240-50.

• Dhamija S, Kuehne N, Winzen R, Doerrie A, Dittrich-Breiholz O, Thakur BK, Kracht M, Holtmann H. Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism. J Biol Chem. 2011 Sep 23;286(38):33279-88.

• Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF. Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells. J Virol. 2011 Oct;85(19):10375-88.

• Schmitz ML, Weber A, Roxlau T, Gaestel M, Kracht M. Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines. Biochim Biophys Acta. 2011 Dec;1813(12):2165-75.

• Dutta P, Koch A, Breyer B, Schneider H, Dittrich-Breiholz O, Kracht M, Tamura T. Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G)) by transcriptome analysis. BMC Genomics. 2011 Apr 1(;12(1):196.

• Geurts J, van den Brand BT, Wolf A, Abdollahi-Roodsaz S, Arntz OJ, Kracht M, van den Berg WB, van de Loo FA. Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts. Rheumatology. (Oxford) 2011 Jul.50(7):1216-25.

4.05

• Gerhard R, Queißer S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I. Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B. Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar 383(3):285-95.

• Gregorovic G, Bosshard R, Karstegl CE, White RE, Pattle S, Chiang AK, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ. Cell gene expression correlating with EBER expression in Epstein-Barr virus infected lymphoblastoid cell lines. J Virol. 2011 Apr.85(7):3535-45.

5.4

2010

• Dinarello C, Arend W, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffmann H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A, Peyman K, van de Veerdonk F, Gabel C. IL-1 family nomenclature. Nat Immunol. 2010 Nov;11(11):973. Erratum in: Nat Immunol. 2011 Mar;12(3):271. Peyman Kelk (corrected to Kelk, Peyman).

• Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M, Holtmann H. IL-1 induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in I kappa B zeta mRNA. J Biol Chem. 2010 Sep 17;(285(38):29165-78.

5.32

• Pietrek M, Brinkmann MM, Glowacka I, Enlud A, Hävemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF. Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation. J Virol. 2010 Aug;84(16):8231-40.

5.15

• Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H. Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation. Cell Death Differ 2010;17(9):1435-47.

8.24

• Weber A, Wasiliew P, Kracht M. Interleukin-1 (Il-1) pathway. Sci Signal. 2010 Jan 19;3(105):cm1.
  See our Science Signaling Maps !

• Weber A, Wasiliew P, Kracht M. Interleukin-1beta (Il-1beta) processing pathway. Sci Signal. 2010 Jan 19;3(105):cm2.
  See our Science Signaling Maps !

2009

• Berg D, Stühmer T, Siegmund D, Müller N, Giner T, Dittrich-Breiholz O, Kracht M, Bargou R, Wajant H. Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways. FEBS J. 2009 Dec;276(23):6912-27.

3.04

• Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D.Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med. 2009 Sep 28;206(10):2161-77.

14.50

• Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner JW, Suerbaum S, Wende E, Rheinheimer C, Klos A.Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease. Inflamm Bowel Dis. 2009 Aug 27;15(12):1812-23.

4.64

• Wang L, Pietrek M, Brinkmann MM, Hävemeier A, Fischer I, Hillenbrand B, Dittrich-Breiholz O, Kracht M, Chanas S, Blackbourn DJ, Schulz TF. Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus. J Gen Virol. 2009 May;90(Pt5):1190-201.

3.26

• Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML. Phosphorylation of NF-kappaB p65 at Ser 468 controls its CommD1-dependent ubiquitation and target gene-specific proteasomal elimination EMBO Rep. 2009 Apr;10(4):381-6.

6.90

• Mosa A, Trumstedt C, Eriksson E, Soehnlein O, Heuts F, Janik K, Klos A, Dittrich-Breiholz O, Kracht M, Hidmark A, Wigzell H, Rottenberg ME. Non-hematopoietic cells control the outcome of infection with Listeria monocytogenes in an NOD1-dependent manner. Infect Immun. 2009;77(7):2908-18.

4.20

• Gaestel M, Kotlyarov A, Kracht M. Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov. 2009 Jung;8(6):480-99.

29.05

• Gaestel M, Kracht M. Peptides as Signaling Inhibitors for Mammalian MAPK Kinase Cascades. Curr Pharm Des 2009; 15(21):2471-80. Review.

4.41

2008

• del Rio ML, Rodriguez-Barbosa JI, Bölter J, Ballmaier M, Dittrich-Breiholz O, Kracht M, Jung S, Förster R. CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties. J Immunol. 2008 Nov 1;181(9):6178-88. PubMed

6.06

• Gabellini C, Castellini L, Trisciuoglio D, Kracht M, Zupi B Del Bufalo D. Involvement of nuclear factor-kappa B in bcl-xl-induced interleukin 8 expression in glioblastoma. J Neurochem. 2008 Nov;107(3):871-82. Epub 2008 Sep 11. PubMed

4.45

• Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ. Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2. J Virol. 2008 Aug;82(15):7456-66. PubMed

5.33

• Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M. c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene. Mol Cell Biol. 2008 Jul;28(13):4407-23.

6.42

• Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackmann N, Kracht M. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. J Biol Chem. 2008 May 2;283(18):12120-8.

5.58

2007

• Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H. Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Mol Cell Biol. 2007 Dec;27(23):8388-400. Epub 2007 Oct 1.

6.42

• Wang L, Brinkmann MM, Pietrek M, Ottinger M, Dittrich-Breiholz O, Kracht M, Schulz TF. Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. J Gen Virol 2007 Jun;88(Pt 6):1698-707.

3.12

• Brinkmann MM, Pietrek M, Dittrich-Breiholz, O, Kracht M, Schulz TF. Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus. J Virol 2007 Jan;81(1):42-58.

5.33

• Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, MArusic S, Lin LL, Gaestel M, Telliez JB. The mitogen-activated protein kinase (MAPK)-activated protein kinases MK1 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol. 2007 Jan;27(1):170-81.

6.42

• Autenrieth SE, Soldanova I, Rösemann R, Gunst D, Zahir N, Kracht M, Ruckdeschel K, Wagner H, Borgmann S, Autenrieth IB. Yersinia enterocolitica YopP inhibits MAP kinase-mediated antigen uptake in dendritic cells. Cell Microbiol. 2007 Feb;9(2):425-37.

5.29

• Kracht M. Targeting Strategies to Modulate the NF-kappaB and JNK Signal Transduction Network. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2007; 6: 71-84.

• Kracht M, Holtmann H. Cytokines. Invited contribution to "Encyclopedic references to molecular pharmacology" Springer Verlag, (update 2007).

2006

• Purwar R, Wittmann M, Zwirner J, Oppermann M, Kracht M, Dittrich-Breiholz O, Gutzner R, Werfel T. Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions. J Immunol. 2006 Oct 1;177(7):4444-50.

6.29

• Spender LC, Lucchesi W, Bodelon G, Bilancio A, Karstegl CE, Asano T, Dittrich-Breiholz O, Kracht M, Vanhaesebroeck B, Farrell PJ. Cell target genes of Epstein-Barr virus transcription factor EBNA-2: inducution of the p55alpha regulatory subunit of PI3-kinase and ist role in survival of EREB2.5 cells. J Gen Virol. 2006 Oct;87(Pt 10):2859-67

3.11

• Ansari AW, Bhatnagar N, Dittrich-Breiholz O, Kracht M, Schmidt RE, Heiken H. Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regualted in HIV type 1 (HIV-1)-infected individuals. Int Immunol. 2006 Oct;18(10):1443-51.

4.01

• Thiefes A, Wolf A, Doerrie A, Grassl GA, Matsumoto K, Autenrieth I, Bohn E, Sakurai H, Niedenthal R, Resch K, Kracht M. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep. 2006 Aug;7(8):838-44.

8.17

• Kettner-Buhrow D, Dittrich-Breiholz O, Schneider H, Wolter S, Resch K, Kracht M. Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independet from the TAK1-NFkappaB-MAPK signaling pathways. Biochem Biophys Res Commun. 2006 Sep 1;347(3):566-73.

2.85

• Schmeck B, Huber S, Moog K, Zahlten J, Hocke AC, Opitz B, Hammerschmidt S, Mitchell TJ, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L730-L737.

3.93

• Gowrishankar G, Winzen R, Dittrich-Breiholz O, Redich N, Kracht M, Holtmann H. Inhibition of mRNA deadenylation and degradation by different types of cell stress. Biol Chem 2006 Mar;387(3):323-7.

2.75

• Schröder N, Sekhar A, Geffers I, Müller J, Dittrich-Breiholz O, Kracht M, Wedemeyer J, Gossler A. Identification of mouse genes with highly specific expression patterns indifferentiated intestinal epithelium. Gastroenterology. 2006 Mar;130(3):902-7.

12.45

• Mattioli I, Geng H, SebaldA, Hodel M, Bucher C, Kracht M, Schmitz ML. Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon. J Biol Chem. 2006 Mar 10;281(10):6175-83.

5.80

2005

• Gowrishankar G, Winzen R, Bollig F, Ghebremedhin B, Redich N, Ritter B, Resch K, Kracht M, Holtmann H. Inhibition of mRNA deadenylation and degrataion by ultraviolet light. Biol Chem. 2005 Dec;386(12):1287-93.

2.57

• Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich Breiholz O, Kracht M, Mrabet-Cahbi S, Werfel T. Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatits. Clin Exp Allergy. 2005 Aug;35(8):1088-95.

3.55

• Schmeck B, Beermann W, van Laak V, Zahlten J, Optiz B, Witzenrath M, Hocke AC, Chakraborty T, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification. J Immunol. 2005 Sep 1;175(5):2843-50.

6.38

• Siegmund D, Wicovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H. Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Mol Cell Biol. 2005 Aug;25(15):6363-79.

7.09

• Peters J, Hess S, Endlich K, Thalmann J, Holzberg D, Kracht M, Schaefer M, Bartling G, Klos A. Silencing or permanent activation: host-cell responses in models of persistent Chlamydia pneumoniae infection. Cell Microbiol. 2005 Aug;7(8):1099-108.

6.33

• Thiefes A, Wolter S, Mushinski JF, Hoffmann E, Dittrich-Breiholz O, Graue N, Dörrie A, Schneider H, Wirth D, Luckow B, Resch K, Kracht M. Simultaneous blockade of NFkappaB, JNK and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes. J Biol Chem. 2005 Jul 29;280(30):27728-41. Epub 2005 Apr 18. Erratum in: J Biol Chem 2005 Sep 16;280(37):32564.

5.85

• Hoffmann E, Thiefes A, Buhrow D, Dittrich-Breiholz O, Schneider H, Resch K, Kracht M. MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors. J Biol Chem. 2005 Mar 11;280(10):9706-18.

5.85

2004

• Buss H, Dörrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M. Constitutive an interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK {beta}, IKK{epslion}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J Biol Chem. 2004 Dec 31;279(53):55633-43. Epub 2004 Oct 15.

6.35

• Schmedk B, Zahlten J, Moog K, van Laak V, Huber S, Hocke AC, Opitz B, Hoffmann E, Kracht M, Zerrahn J, Hammerschmidt S, Rosseau S, Suttorp N, Hippenstieol S. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RElA at the interleukin-8 promotor. J Biol Chem. 2004 Nov 26;279(51):53241-7.

6.35

• Buss H, Dörrie A, Schmitz ML, Frank R, Livingstone M, Resch K, Kracht M. Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J Biol Chem. 2004 Nov 26;279(48):49571-4.

6.35

• Kreuz S, Siegmund D, Rumpf JJ, Samel D, Leverkus M, Janssen O, Häcker G, Dittrich-Breiholz O, Kracht M, Scheurich P, Wajant H. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. J Cell Biol. 2004 Aug 2;166(3):369-80.

11.60

• Mattioli I, Dittrich-Breiholz O, Livingstone M, Kracht M, Schmitz ML. Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes. Blood. 2004 Nov 15;104(10):3302-4.

9.78

• Mattioli I, Sebald A, Bucher C, Chales RP, Nakano H, Doi T, Kracht M, Schmitz ML. Transient and selective NF-kappa B p65 phosphorylation induced by T cell costimulation ist mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. J immunol. 2004 May 15;172(10):6336-44.

6.48

• Schmitz ML, Mattioli I, Buss H, Kracht M. NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem. 2004 Oct 4;5(10):1348-58. Review.

3.47

• Kracht M, Holtmann H. Cytokines. Invited contribution to "Encyclopedic reference of Genomics and Proteomics in Molecular Medicine". Springer Verlag (2004).

2003

• Grassl GA, Kracht M, Wiedemann A, Hoffmann E, Aepfelbacher M, von Eichel-Streiber C, Bohn E, Autenrieth IB. Activation of NF-kappaB and IL-8 by Yersinio enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades. Cell Microbiol. 2003 Dec;5(12):957-71.

5.33

• Bömmel H, Haake M, Luft P, Horejs-Hoeck J, Hein H, Bartels J, Schauer C, Pöschl U, Kracht M, Duschl A. The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin. Int Immunopharmacol. 2003 Oct;3(10-11):1371-9.

2.20

• Holzberg D, Knight CG, Dittrich-Breiholz O, Schneider H, Dörrie A, Hoffmann E, Resch K, Kracht M. Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-Jun delta domain induces apoptoisis and affects a distinct set of interleukin-1-induced inflammatory genes. J Biol Chem.2003 Oct 10;278(41):40213-23.

6.48

• Sarker KP, Biswas KK, Yamakuchi M, Lee KY, Hahiguchi T, Kracht M, Kitajima I, Maruyama I. ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. J Neurochem. 2003 Apr;85(1):50-61.

4.82

• Dittrich-Breiholz, O., Schneider, H., Wehmeier, L., Resch, K., Kracht, M. Entwicklung und Evaluierung eines DNA Mikro Arrays für entzündungsrelevante Gene. Biospektrum 1/03, 88-92 (2003).

• Wehmeier, L., Dittrich-Breiholz, O., Kracht, M. Biochips in klinischen Applikationen: Ermittlung von Genexpressionsprofilen im Entzündungsprozess. Managment und Krankenhaus, (2003).

2002

• Bollig F, Winzen R, Kracht M, Ghebremedhin B, Ritter B, Wilhelm A, Resch K, Holtmann H. Evidence for general stabilization of mRNAs in response to UV light. Eur J Biochem. 2002 Dec;269(23):5830-9.

2.99

• Hipp MS, Urbich C, Mayer P, Wischhusen J, Weller M, Kracht M, Spyridopoulos I. Proteasome inhibition leads to NF-kappaB-independent IL-8 transactivation inhuman endothelial cells through induction of AP-1. Eur J Immunol. 2002 Aug;32(8):2208-17.

4.83

• Wolter S, Mushinski JF, Saboori AM, Resch K, Kracht M. Inducible expression of a constitutively active mutant of mitogen-activated protein kinase kinase 7specifically activates c-JUN NH2-terminal protein kinase, alters expression of atleast nine genes, and inhibits cell proliferation. J Biol Chem. 2002 Feb 1;277(5):3576-84.

6.69

• Kracht M, Saklatvala J. Transcriptional and post-transcriptional control of gene expression in inflammation. Cytokine. 2002 Nov 7;20(3):91-106. Review. No abstract available.

2.37

• Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol. 2002 Nov;72(5):847-55. Review.

4.13

• Kracht M.. Signal-dependent regulation of interleukin-8 gene expression. In: Recent Research Developments in Molecular and Cellular Biology, Research Signpost, Trivandrum, India, (2001). Recent Res.Devel.Mol.Cell.Biol., 3:329-342, (2002) (Review).

• Kracht, M., Holtmann, H. Cytokines. Invited contribution to „Encyclopedic references to molecular pharmacology“. Springer Verlag, (2002).

2001

• Ludwig S, Ehrhardt C, Neumeier ER, Kracht M, Rapp UR, Pleschka S.Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway. J Biol Chem. 2001 Apr 6;276(14):10990-8. Epub 2001 Jan 9.Corrected and republished in: J Biol Chem. 2001 Jun 15;276(24):10990-8.

7.25

• Nourbakhsh M, Kalble S, Dorrie A, Hauser H, Resch K, Kracht M. The NF-kappa b repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappa b-flanking sequence element. J Biol Chem. 2001 Feb 9;276(6):4501-8.

7.25

• Holtmann H, Enninga J, Kalble S, Thiefes A, Dorrie A, Broemer M, Winzen R, Wilhelm A, Ninomiya-Tsuji J, Matsumoto K, Resch K, Kracht M. The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation. J Biol Chem. 2001 Feb 2;276(5):3508-16.

7.25

• Schmitz ML, Bacher S, Kracht M.I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations. Trends Biochem Sci. 2001 Mar;26(3):186-90. Review.

14.32

2000

• Kracht M. Regulation of cytokine transcription by common stress kinase cascades.
  Eur Cytokine Netw. 2000 Sep;11(3):497-9

1.69

1999

• Varga G, Dreikhausen U, Kracht M, Appel A, Resch K, Szamel M. Molecular mechanisms of T lymphocyte activation: convergence of T cell antigen receptor and IL-1 receptor-induced signaling at the level of IL-2 gene transcription. Int Immunol. 1999 Nov;11(11):1851-62.

2.89

• Holtmann H, Winzen R, Holland P, Eickemeier S, Hoffmann E, Wallach D, Malinin NL, Cooper JA, Resch K, Kracht M. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Mol Cell Biol. 1999 Oct;19(10):6742-53.

9.86

• Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, Müller M, Gaestel M, Resch K, Holtmann H. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 1999 Sep 15;18(18):4969-80.

13.97

1998

• Krause A, Holtmann H, Eickemeier S, Winzen R, Szamel M, Resch K, Saklatvala J, Kracht M. Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB. J Biol Chem. 1998 Sep 11;273(37):23681-9.

1997

• Finch A, Holland P, Cooper J, Saklatvala J, Kracht M. Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7.
  FEBS Lett. 1997 Nov 24;418(1-2):144-8.

• Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem. 1997 Mar 21;272(12):7727-31.

• Kracht M, Finch A, Saklatvala J. Interleukin-1 activates a novel p54 MAP kinase in rabbit liver. In: NATO-ASI Series, Vol H102. Interacting protein domains: Their role in Signal and Energy Transduction. Edited by Ludwig Heilmeyer. Springer-Verlag Berlin Heidelberg 1997, 157-160 (1997).

1996

• Appel A, Kracht M, Petersen K, Resch K, Szamel M. Interleukin-1 induced signalling: biphasic activation of mitogen-activated protein kinase kinase and mitogen-activated protein kinases in HeLa cells. Involvement of phosphoprotein phosphatases.
  Eur Cytokine Netw. 1996 Dec;7(4):775-84.

• Uciechowski P, Saklatvala J, von der Ohe J, Resch K, Szamel M, Kracht M. Interleukin 1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells. FEBS Lett. 1996Oct 7;394(3):273-8.

1995

• Zinck R, Cahill MA, Kracht M, Sachsenmaier C, Hipskind RA, Nordheim A. Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. Mol Cell Biol. 1995 Sep;15(9):4930-8.

1994

• Kracht M, Truong O, Totty NF, Shiroo M, Saklatvala J. Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver. J Exp Med. 1994 Dec 1;180(6):2017-25.

• Kracht M, Shiroo M, Marshall CJ, Hsuan JJ, Saklatvala J. Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669. Biochem J. 1994 Sep 15;302 ( Pt 3):897-905.

1993

• Saklatvala J, Rawlinson LM, Marshall CJ, Kracht M. Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells. FEBS Lett. 1993 Nov 15;334(2):189-92.

• Kracht M, Heiner A, Resch K, Szamel M. Interleukin-1-induced signaling in T-cells. Evidence for the involvement of phosphatases PP1 and PP2A in regulating protein kinase C-mediated protein phosphorylation and interleukin-2 synthesis. J Biol Chem. 1993 Oct 5;268(28):21066-72.

• Szamel M, Kracht M, Krebs B, Hübner U, Resch K. Activation signals in human lymphocytes: interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C.
  Cell Immunol. 1990 Mar;126(1):117-28.