SFB 1021 "RNA Viruses: RNA Metabolism, Host Response and Pathogenesis", project C02
Project C02: "Regulation of RNA metabolism, translation and protein degradation pathways in the host response to coronavirus infection"
Short summary:
The molecular mechanisms that determine coronavirus pathology at the cellular level are incompletely understood and new concepts are needed to suppress viral replication. Based on results from multi-level molecular analyses we will identify (i) the chromatin-based functions of CoV-activated transcription factors, (ii) the roles of ER stress kinases in selective translation, (iii) the host cell factors required for CoV replication and (iv) the molecular basis for the antiviral effects of the ER stressor thapsigargin with the long-term aim to unravel intracellular key nodes of signaling that distinguish adapted from highly pathogenic CoV and that are amenable to therapeutic intervention.
... WEB page SFB 1021 (called collaborative research center (CRC 1021)