Publications
Key Publications
- The inner nuclear membrane Lem2 coordinates RNA degradation at the nuclear periphery.
Martín Caballero L, Capella M, Barrales RR, Dobrev N, van Emden T, Hirano Y, Suma Sreechakram VN, Fischer-Burkart S, Kinugasa Y, Nevers A, Rougemaille M, Sinning I, Fischer T, Hiraoka Y, and Braun S*
Nature Struct & Mol Biol 2022 29(9):910-921. doi: 10.1038/s41594-022-00831-6.
Article - Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.
Capella M*, Mandemaker IK, Martín Caballero L, den Brave F, Pfander B, Ladurner AG, Jentsch S, and Braun S*
Nature commun. 2021 12(1):4918. doi: 10.1038/s41467-021-25205-2.
Article - Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability.
van Emden TS, Forn M, Forné I, Sarkadi Z, Capella M, Martín Caballero L, Fischer‐Burkart S, Brönner C, Simonetta M, Toczyski D, Halic M, Imhof A and Braun S.
EMBO Rep. 2018 e47181; DOI 10.15252/embr.201847181
Article - The histone acetyltransferase Mst2 protects active chromatin form epigenetic silencing by acetylating the ubiquitin ligase Brl1.
Flury V, Georgescu PR, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S*, and Bühler M *
Mol Cell. 2017 67(2):294-307.
Article - Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
Barrales RR, Forn M, Georgescu P, Sarkadi Z, Braun S*
Genes Dev. 2016 30(2): 133-48.
Article - The ubiquitin ligase Cul4-Ddb1Cdt2 inhibits the invasion of a boundary-associated anti-silencing factor into heterochromatin.
Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD*
Cell 2011 144(1):41-54.
Article
* (co-) corresponding author(s)
All Publications
2021 - 2022
- Proteome effects of genome-wide single gene perturbations
Özturk M, Freiwald A, Cartano J, Schmitt R, Dejung M, Luck J, Al-Sady B, Braun S, Levin M and Butter F.
Nature commun. 2022 13(1): 6135. doi: 10.1038/s41467-022-33814-8
Article - The inner nuclear membrane Lem2 coordinates RNA degradation at the nuclear periphery.
Martín Caballero L, Capella M, Barrales RR, Dobrev N, van Emden T, Hirano Y, Suma Sreechakram VN, Fischer-Burkart S, Kinugasa Y, Nevers A, Rougemaille M, Sinning I, Fischer T, Hiraoka Y, and Braun S.
Nature Struct & Mol Biol 2022 29(9):910-921. doi: 10.1038/s41594-022-00831-6.
Article - Chaperoning heterochromatin: new roles of FACT in chromatin silencing
Murawska M* and Braun S
Trend Genetics 2022 38(7):646-649. doi: 10.1016/j.tig.2022.02.011.
Article - Local chromatin context dictates the genetic determinants of the heterochromatin spreading reaction
Greenstein RA, Ng H, Barrales RR, Tan C, Braun S, Al-Sady B* .
PLOS Genetics 2022 18(5): e1010201. Doi: 10.1371/journal.pgen.1010201
Article - The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.
Murawska M, Greenstein RA, Schauer T, Olsen KCF, Ng H, Ladurner AG, Al-Sady B and Braun S.
Cell Rep. 2021, DOI:https://doi.org/10.1016/j.celrep.2021.109944
Article - Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.
Capella M, Mandemaker IK, Caballero Martín L, den Brave F, Pfander B, Ladurner AG, Jentsch S. and Braun S.
Nat Commun. 2021 Aug 13;12(1):4918. doi: 10.1038/s41467-021-25205-2.
Article - Crosstalk between H2A variant-specific modifications impacts vital cell functions.
Schmücker A, Lei B, Lorković ZJ, Capella M, Braun S, Bourguet P, Mathieu O, Mechtler K and Berger F.
PLoS Genet. 2021, Jun 4;17(6):e1009601. doi: 10.1371/journal.pgen.1009601. eCollection 2021 Jun.
Article
2019-2020
- ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing
Capella M, Caballero LM, Pfander B, Braun S and Jentsch S
J Cell Sci. 2020, Dec 21;133(24):jcs250688. doi: 10.1242/jcs.250688.
Article - A Synthetic Approach to Reconstruct the Evolutionary and Functional Innovations of the Plant Histone Variant H2A.W
Lei B, Capella M, Montgomery SA, Borg M, Osakabe A, Goiser M, Muhammad A, Braun S and Berger F.
Curr Biol. 2020, Oct 15; S0960-9822(20)31491-3
Article - ESCRTing Heterochromatin Out of the Nuclear Periphery.
Capella M and Braun S.
Developmental Cell 2020, Volume 53, Issue 1, Pages 27-41.e6
Article - The euchromatic histone mark H3K36me3 preserves heterochromatin through sequestration of an acetyltransferase complex in fission yeast.
Georgescu PR, Capella M, Fischer-Burkart S and Braun S.
Microb Cell. 2020, Jan 3;7(3):80-92. doi: 10.15698/mic2020.03.711.
Article - Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability.
Greenstein RA, Barrales RR, Sanchez NA, Bisanz JE, Braun S, Al-Sady B.
Genes Dev. 2019 Dec 5. doi: 10.1101/gad.328468.119. [Epub ahead of print]
Article - Neutral epigenetic inheritance: being prepared for future generations.
Capella M, Braun S.
Nat Struct Mol Biol. 2019; May 20. doi: 10.1038/s41594-019-0239-5.
Article - TASks for subtelomeres: when nucleosome loss and genome instability are favored.
van Emden TS, Braun S.
Curr Genet. 2019; May 7. doi: 10.1007/s00294-019-00986-8. Review.
Article - Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability.
van Emden TS, Forn M, Forné I, Sarkadi Z, Capella M, Martín Caballero L, Fischer‐Burkart S, Brönner C, Simonetta M, Toczyski D, Halic M, Imhof A and Braun S.
EMBO Rep. 2019 e47181; DOI 10.15252/embr.201847181
Article
2014-2018
- The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S, Gallardo P, Barrales RR, Braun S and Daga RR.
J Cell Biol. 2017; 216(11), 3591-3608.
Article - The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.
Flury V, Georgescu PR, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S and Bühler M.
Mol Cell. 2017; 67, 1–14.
Article - Beyond Tethering and the LEM domain: MSCellaneous functions of the inner nuclear membrane Lem2.
Braun S* and Barrales RR.
Nucleus 2016 7(6): 523-531. Mini-Review
Article - Chromatin binding and silencing: Two roles of the same protein Lem2.
Barrales RR*, Braun S*
Microbial Cell 2016 3(4): 185-188. Commentary
Article - Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.
Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD.
PLoS One. 2016 Aug 1;11(8):e0159292.
PubMed - Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
Barrales RR, Forn M, Georgescu PR, Sarkadi Z, and Braun S.
Genes Dev. 2016 Jan 7.
Article - Global regulation of heterochromatin spreading by Leo1.
Verrier L, Taglini F, Barrales RR, Webb S, Urano T, Braun S, and Bayne EH.
Open Biol. 2015 May;5(5): pii: 150045. doi: 10.1098/rsob.150045.
PubMed - Relationship between genome and epigenome—challenges and requirements for future research.
Almouzni G, Altucci, L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S et al.
BMC Genomics 2014. 15(487):1-7 Correspondence
Article
2008-2013
- Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.
Braun S and Madhani HD.
EMBO Rep. 2012 Jun 29;13(7):619-30.
PubMed - Ers1 links HP1 to RNAi.
Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD.
Proc Natl Acad Sci U S A. 2012 Jun 25. [Epub ahead of print]
PubMed - The ubiquitin ligase Cul4-Ddb1Cdt2 inhibits the invasion of a boundary-associated anti-silencing factor into heterochromatin.
Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD (2011).
Cell 144(1):41-54.
Article - Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe. Rougemaille M, Shankar S, Braun S, Rowley M, Madhani HD (2008).
J Biol Chem. 283(38):25770-3.
PubMed - A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.
Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS (2008). Nat Methods. 5(8):711-8.
PubMed
2000-2007
- SM-protein-controlled ER-associated degradation discriminates between different SNAREs.
Braun S, Jentsch S. (2007).
EMBO Rep. 8(12):1176-82.
PubMed - A Series of Ubiquitin-Binding Factors Connects CDC48/p97 to Substrate Multiubiquitylation and Proteasomal Targeting.
Richly H, Rape M, Braun S, Rumpf S, Hoege C and Jentsch S (2005).
Cell 120(1):73-84.
PubMed - Role of the Ubiquitin-selective CDC48UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates.
Braun S, Matuschweski K, Rape M, Thoms S and Jentsch S (2002).
EMBO J 21, 614-621.
PubMed - Dexamethasone-enhanced sensitivity of mouse hippocampal HT22 cells for oxidative stress is associated with the suppression of nuclear factor-kappaB.
Braun S, Liebetrau W, Berning B, Behl C (2000).
Neurosci Letters 295:101-4.
PubMed - Glutathione and a UV light-induced glutathione S-transferase are involved in signaling to chalcone synthase in cell cultures.
Loyall L, Uchida K, Braun S, Furuya M, Frohnmeyer H (2000).
Plant Cell 12:1939-50.
PubMed