ausgewählte Publikationen

Kratzer M-C., Becker S.F.S, Grund A., Merks A., Harnos J., Bryja V., Giehl K., Kashef J., Borchers A. The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelld. Development 22;147(10), 2020

Seiz J.R., Klinke J., Scharlibbe L., Lohfink; d., Heipel M., Ungefroren H., Giehl K*., Menke A*. Different signaling and functionality of Rac1 and Rac1b in the progression of lung adenocarcinoma. Biol. Chem. 401(4):517-531, 2020

Meinohl C., Barnard S.J. Fritz-Wolf K., Unger M., Porr A., Heipel M., Wirth S., Madlung J., Nordheim A., Menke A., Becker K., Giehl K. Galectin-8 binds to the farnesylated C-terminus of K-Ras4B and modifes Ras/ERK signaling and migration in pancreatic and lung carcinoma cells. Cancers (Basel). 2019 Dec 20;12(1), 2019

Schirmer B, Giehl K, Kubatzky K.F. Report of the Signal Transduction Meeting 2018 - Signaling from Past to Future. Int J Mol Sci 2019, Jan 8;20(1), 2019

Schirmer B, Giehl K, Kubatzky K.F. Report of the Signal Transduction Meeting 2017 - Metabolism in Health and Disease. Int J Mol Sci 2018, Feb12,19(2), 2018

Witte D., Otterbein H. Förster M., Giehl K., Zeiger R., Lehnert H., Ungefroren H. Negative regulation of TGFbeta1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b. Sci Rep 2017 Dec11;7(1):17313, 2017

Sommer N., Hütemann M., Pak O., Scheibe S., Knoepp F., Sinkler C, Malczyk M., Gierhardt M., Esfandiary A., Kraut S, Jonas F, Veith C., Aras S., Sydykov A., Alebrahimdehkordi N, Giehl K., Hecker M., Brandes RP, Seeger W., Grimminger F., Ghofrani H.A., Schermuly R.T., Grossmann L.I., Weismann N. Mitochondrial complex IV subunit4 Istform 2 ist essentail for acute pulmonary oxygen sensing. Circ Res 121(4):424-438, 2017

Preissner F., Giehl K., Rehm M., Goppelt-Strübe M.: Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad 2 and YAP/TAZ involved in CTGF synthesis. Biochim. Biophys Acta 186(8):2027-36, 2016

Giehl K., Keller C., Hartmann R., Goppelt-Struebe M.: Actin-mediated gene expression depends on RhoA and Rac-1 signaling in proximal tubular epithelial cells. PLoS ONE, 10(3):e0121589, 2015

Ungefroren H., Sebens S., Giehl K., Helm O., Groth S., Fändrich F., Röcken C., Sipos B., Lehnert H, Gieseler F. Rac1b negatively regulates TGF-beta1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling. Oncotarget 5:277-90, 2014.

Weidemann A., Breyer J., Rehm M., Eckardt KU., Daniel C., Cicha I., Giehl K., Goppelt-Struebe M. HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells. Cell Commun Signal. 11:80, 2013.

Menke A., Giehl K. Regulation of adherens junctions by Rho GTPases and p120-catenin. Arch. Biochem. Biophys., Special issue: Cell-Cell Communication in Development and Disease, 524:48-55, 2012.

Minjgee M., Toulany M., Kehlbach R., Giehl K., Rodemann H.P. K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs. Int. J. Radiat Oncol Biol Phys. 81: 1506-14, 2011.

Nuessle J., Giehl K., Herzog R., Stracke S., Menke A. TGFβ1 suppresses vascular smooth muscle cell motility by expression of N-cadherin. Biological Chemistry 392:461-75, 2011.

Kleger A., Seufferlein T., Malan D., Tischendorf M., Storch A., Wolheim A., Latz S., Protze S., Porzner M., Proepper C., Brunner C., Katz S.-F., Pusapati G.V., Bullinger L., Köhntop R., Giehl K., Spyrantis A., Wittekindt O., Lin Q., Zenke M., Fleischmann B.K., Wartenberg M., Wobus A.M., Boeckers T.M., and Liebau , S. Modulation of calcium activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation 122:1823-1836; 2010.

Hage B., Meinel K., Baum I., Menke A, and Giehl K. Rac1 activation inhibits E-Cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells. Cell Communication and Signaling, 7:23, 2009.

Dietrich K.-A., Schwarz R., Liska M., Graß S., Menke A., Meister M., Kierschke G., Längle C., Genze F., Giehl K. Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC which differs from RhoA in its localization and activity. Biological Chemistry 390:1063-77, 2009.

Eisenberg S., Giehl K., Henis Y., and Ehrlich M. Selective interference of chlorpromazine with the membrane interactions of constitutively active K-Ras and its effects on cell growth. J.Biol.Chem. 238: 27279-27288. 2008.

Schreiber S.C., Giehl K., Kastilan C., Hasel C., Mühlenhoff M., Adler G., Wedlich D., Menke A. Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells. Gastroenterology 134:1555-1566, 2008.

Giehl K., Menke A. Microenvironmental regulation of E-cadherin-mediated adherens junctions. Frontier in Bioscience 13:3975-3985, 2008.

Giehl K., Graness, A., and Goppelt-Struebe M. The small GTPase Rac1 is a regulator of mesangial cell morphology and thrombospondin expression. Am J Physiol Renal Physiol. 294: F407-13, 2008.  

Dreissigacker U., Mueller M.S. Unger M., Siegert P., Genze F., Gierschik P., and Giehl K. Oncogenic K-Ras mediates enhanced migration and invasion of pancreatic carcinoma cells through activation of p38. Cell Signaling 18:1156-1168, 2006.

Giehl K. Oncogenic Ras in tumour progression and metastasis. Biol. Chem. 386:193-205, 2005.

Imamichi Y., Waidmann O., Hein R., Eleftheriou P., Giehl K., Menke A. TGFβ-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4. Biol. Chem., 386:225-236, 2005.

Veit C., Genze F., Menke A., Hoeffert S., Gress T.M., Gierschik P., and Giehl K. Activation of PI 3-kinase and ERK is required for GDNF-induced migration and invasion of pancreatic carcinoma cells. Cancer Res. 64:5291-5300, 2004.

Giehl K., Fensterer H., Buchholz M., Ellenrieder V., Buck A., Kestler H.A., Adler G., Gierschik P., and Gress T.M. Expression profiling of the influence of Ras mutants on the TGFβ-induced phenotype of pancreatic cancer cells. Genes Chromosomes Cancer 39:224-235, 2004.

Stähle M., Veit C., Bachfischer, U., Schierling K., Skripczynski B., Hall A., Gierschik, P., and Giehl K. Mechanisms in LPA-induced tumor migration: critical role of phosphorylated ERK. J. Cell Science 116: 3835-3846, 2003.

Giehl K., Skripczynski B., Mansard A., Menke A., and Gierschik P. Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene 19: 2930-2942, 2000.    

Weisz B., Giehl K., Gana-Weisz M., Egozi Y., Ben-Baruch G., Marciano D., Gierschik P., and Kloog Y. A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. Oncogene 18: 2579-2588, 1999.