Overview Publications

Original Research

Qi, H., H. Liu, S. S. Pullamsetti, S. Günther, C. Kuenne, A. Atzberger, N. Sommer, S. Hadzic, A. Günther, N. Weissmann, Y. Zhou, X. Yuan and T. Braun. "Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease." Circulation (2021). 144(13): 1042-1058 DOI: 10.1161/circulationaha.120.051680. PMID: 34247492

Saraji, A., A. Sydykov, K. Schäfer, C. F. Garcia-Castro, I. Henneke, N. Alebrahimdehkordi, D. Kosanovic, S. Hadzic, A. Guenther, M. Hecker, H. A. Ghofrani, W. Seeger, R. T. Schermuly, N. Weissmann, N. Sommer and O. Pak. "PINK1-mediated Mitophagy Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension." Am J Respir Cell Mol Biol (2021). 65(2): 226-228 DOI: 10.1165/rcmb.2021-0082LE. PMID: 34328407

Wujak, M., C. Veith, C. Y. Wu, T. Wilke, Z. I. Kanbagli, T. Novoyatleva, A. Guenther, W. Seeger, F. Grimminger, N. Sommer, R. T. Schermuly and N. Weissmann. "Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways." Int J Mol Sci (2021). 22(19) DOI: 10.3390/ijms221910371. PMID: 34638712 PMCID: PMC8508902

Gredic, M., C. Y. Wu, S. Hadzic, O. Pak, R. Savai, B. Kojonazarov, S. Doswada, A. Weiss, A. Weigert, A. Guenther, R. P. Brandes, R. T. Schermuly, F. Grimminger, W. Seeger, N. Sommer, S. Kraut and N. Weissmann. "Myeloid cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice." Eur Respir J (2021). DOI: 10.1183/13993003.01153-2021. PMID: 34475225

Giordano, L., M. K. Aneja, N. Sommer, N. Alebrahimdehkordi, A. Seraji, N. Weissmann, C. Rudolph, C. Plank, H. T. Jacobs and M. Szibor. "Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active." Gene Ther (2021). DOI: 10.1038/s41434-021-00235-z. PMID: 33664504

Gall, H., A. Yogeswaran, J. Fuge, N. Sommer, F. Grimminger, W. Seeger, K. M. Olsson, M. M. Hoeper, M. J. Richter, K. Tello and H. A. Ghofrani. "Validity of echocardiographic tricuspid regurgitation gradient to screen for new definition of pulmonary hypertension." EClinicalMedicine (2021). 34: 100822 DOI: 10.1016/j.eclinm.2021.100822. PMID: 33997731 PMCID: PMC8102717

Sommer N, Noack S, Hecker A, Hackstein H, Bein G, Weissmann N, Seeger W, Mayer K, Hecker M. Decreased Thymic Output Contributes to Immune Defects in Septic Patients. J Clin Med. 2020 Aug 20;9(9):E2695. doi: 10.3390/jcm9092695. PMID: 32825352.

Yogeswaran A, Gall H, Tello K, Grünig E, Xanthouli P, Ewert R, Kamp JC, Olsson KM, Wißmüller M, Rosenkranz S, Klose H, Harbaum L, Lange TJ, Opitz CF, Waelde A, Milger K, Sommer N, Seeger W, Ghofrani HA, Richter MJ. Impact of SARS-CoV-2 pandemic on pulmonary hypertension out-patient clinics in Germany: a multi-centre study. Pulm Circ. 2020 Jul 23;10(3):2045894020941682. doi: 10.1177/2045894020941682. PMID: 32754309; PMCID: PMC7378724.

Seimetz M*, Sommer N*, Bednorz M*, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu CY, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2020 Jun;2(6):532-546. doi: 1038/s42255-020-0215-8. Epub 2020 Jun 8. Erratum in: Nat Metab. 2020 Jul;2(7):648. PMID: 32694733. *equal contribution.

Yogeswaran A, Tello K, Faber M, Sommer N, Kuhnert S, Seeger W, Grimminger F, Ghofrani HA, Richter MJ, Gall H. Risk assessment in severe pulmonary hypertension due to interstitial lung disease. J Heart Lung Transplant. 2020 Oct;39(10):1118-1125. doi: 10.1016/j.healun.2020.06.014. Epub 2020 Jun 25. PMID: 32690230.

Schneck E, Edinger F, Hecker M, Sommer N, Pak O, Weissmann N, Hecker A, Reichert M, Markmann M, Sander M, Koch C. Blood Levels of Free-Circulating Mitochondrial DNA in Septic Shock and Postsurgical Systemic Inflammation and Its Influence on Coagulation: A Secondary Analysis of a Prospective Observational Study. J Clin Med. 2020 Jun 30;9(7):2056. doi: 10.3390/jcm9072056. PMID:32629885; PMCID: PMC7408641.

Hecker M, Rose M, Hecker A, Dietrich H, Schaefer MB, Sommer N, Seeger W, Mayer K. Immunomodulation by an Omega-6 Fatty Acid Reduced Mixed Lipid Emulsion in Murine Acute Respiratory Distress Syndrome. J Clin Med. 2020 Jun 29;9(7):2048. doi: 10.3390/jcm9072048. PMID: 32610690; PMCID: PMC7408915.

Strielkov I, Krause NC, Knoepp F, Alebrahimdehkordi N, Pak O, Garcia C, Ghofrani HA, Schermuly RT, Seeger W, Grimminger F, Sommer N, Weissmann N. Cytochrome P450 epoxygenase-derived 5,6-epoxyeicosatrienoic acid relaxes pulmonary arteries in normoxia but promotes sustained pulmonary vasoconstriction in hypoxia. Acta Physiol (Oxf). 2020 Sep;230(1):e13521. doi: 10.1111/apha.13521. Epub 2020 Jun 22. PMID: 32506676.

Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelković A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M. Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv. 2020 Apr 15;6(16):eaba0694. doi: 10.1126/sciadv.aba0694. PMID: 32426457; PMCID: PMC7159913. 

Yogeswaran A, Richter MJ, Sommer N, Ghofrani HA, Seeger W, Gall H, Tello K. Evaluation of pulmonary hypertension by right heart catheterisation: does timing matter? Eur Respir J. 2020 Sep 3;56(3):1901892. doi: 10.1183/13993003.01892-2019. PMID: 32350102.

Fysikopoulos A, Seimetz M, Hadzic S, Knoepp F, Wu CY, Malkmus K, Wilhelm J, Pichl A, Bednorz M, Tadele Roxlau E, Ghofrani HA, Sommer N, Gierhardt M, Schermuly RT, Seeger W, Grimminger F, Weissmann N, Kraut S. Amelioration of elastase-induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice. Br J Pharmacol. 2020 Mar 22. doi: 10.1111/bph.15057. Epub ahead of print. PMID: 32201936.

Schneck E, Mallek F, Schiederich J, Kramer E, Markmann M, Hecker M, Sommer N, Weissmann N, Pak O, Michel G, Hecker A, Padberg W, Boening A, Sander M, Koch C. Flow Cytometry-Based Quantification of Neutrophil Extracellular Traps Shows an Association with Hypercoagulation in Septic Shock and Hypocoagulation in Postsurgical Systemic Inflammation-A Proof-of-Concept Study. J Clin Med. 2020 Jan 8;9(1):174. doi: 10.3390/jcm9010174. PMID: 31936385; PMCID: PMC7019434.

Richter MJ, Fortuni F, Wiegand MA, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Seeger W, Sommer N, Gall H, Ghio S, Tello K. Association of right atrial conduit phase with right ventricular lusitropic function in pulmonary hypertension. Int J Cardiovasc Imaging. 2020 Apr;36(4):633-642. doi: 10.1007/s10554-019-01763-x. Epub 2020 Jan 8. PMID: 31912453.

Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J. Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. Sci Signal. 2020 Jan 21;13(615):eaay9452. doi: 10.1126/scisignal.aay9452. PMID: 31848220.

Husain-Syed F, Birk HW, Ronco C, Schörmann T, Tello K, Richter MJ, Wilhelm J, Sommer N, Steyerberg E, Bauer P, Walmrath HD, Seeger W, McCullough PA, Gall H, Ghofrani HA. Doppler-Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure. J Am Heart Assoc. 2019 Nov 5;8(21):e013584. doi: 10.1161/JAHA.119.013584. Epub 2019 Oct 19. PMID: 31630601; PMCID: PMC6898799.

Tello K, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Seeger W, Dumitrescu D, Sommer N, Brunst A, Gall H, Richter MJ. Impaired right ventricular lusitropy is associated with ventilatory inefficiency in pulmonary arterial hypertension. Eur Respir J. 2019 Nov 21;54(5):1900342. doi: 10.1183/13993003.00342-2019. PMID: 31515402.

Tello K, Wan J, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Mohajerani E, Seeger W, Herberg U, Sommer N, Gall H, Richter MJ. Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Sep;12(9):e009047. doi: 10.1161/CIRCIMAGING.119.009047. Epub 2019 Sep 10. PMID: 31500448; PMCID: PMC7099862.

Tello K, Ghofrani HA, Heinze C, Krueger K, Naeije R, Raubach C, Seeger W, Sommer N, Gall H, Richter MJ. A simple echocardiographic estimate of right ventricular-arterial coupling to assess severity and outcome in pulmonary hypertension on chronic lung disease. Eur Respir J. 2019 Sep 12;54(3):1802435. doi: 10.1183/13993003.02435-2018. PMID: 31073085.

Pichl A*, Sommer N*, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O, Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA, Weissmann N. Riociguat for treatment of pulmonary hypertension in COPD: a translational study. Eur Respir J. 2019 Jun 27;53(6):1802445. doi: 10.1183/13993003.02445-2018. PMID: 30956210. *equal contribution

Esfandiary A, Kutsche HS, Schreckenberg R, Weber M, Pak O, Kojonazarov B, Sydykov A, Hirschhäuser C, Wolf A, Haag D, Hecker M, Fink L, Seeger W, Ghofrani HA, Schermuly RT, Weißmann N, Schulz R, Rohrbach S, Li L, Sommer N*, Schlüter KD*. Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing. Cardiovasc Res. 2019 Jun 1;115(7):1217-1227. doi: 10.1093/cvr/cvz049. PMID: 30850841; PMCID: PMC6529920. *equal contribution.

Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M. Resolvin E1 Improves Mitochondrial Function in Human Alveolar Epithelial Cells during Severe Inflammation. Lipids. 2019 Jan;54(1):53-65. doi: 10.1002/lipd.12119. Epub 2019 Jan 29. PMID: 30697748.

Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M. Alternative Oxidase Attenuates Cigarette Smoke-induced Lung Dysfunction and Tissue Damage. Am J Respir Cell Mol Biol. 2019 May;60(5):515-522. doi: 10.1165/rcmb.2018-0261OC. PMID: 30339461; PMCID: PMC6503618.

Sommer N, Droege F, Gamen KE, Geisthoff U, Gall H, Tello K, Richter MJ, Deubner LM, Schmiedel R, Hecker M, Spiekerkoetter E, Wirsching K, Seeger W, Ghofrani HA, Pullamsetti S. Treatment with low-dose tacrolimus inhibits bleeding complications in a patient with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension. Pulm Circ. 2019 Apr-Jun;9(2):2045894018805406. doi: 10.1177/2045894018805406. Epub 2018 Sep 27. PMID: 30260738; PMCID: PMC6432681.

Hecker M, Sommer N, Foch S, Hecker A, Hackstein H, Witzenrath M, Weissmann N, Seeger W, Mayer K. Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1016-1028. doi: 10.1016/j.bbalip.2018.06.011. Epub 2018 Jun 12. PMID: 29902569.

Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N. Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension. Eur Respir J. 2018 Feb 1:1701024. doi: 10.1183/13993003.01024-2017. Epub ahead of print. PMID: 29419444.

Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circ Res. 2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482. Epub 2017 Jun 15. PMID: 28620066; PMCID: PMC5544581.

Gall H, Felix JF, Schneck FK, Milger K, Sommer N, Voswinckel R, Franco OH, Hofman A, Schermuly RT, Weissmann N, Grimminger F, Seeger W, Ghofrani HA. The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups. J Heart Lung Transplant. 2017 Sep;36(9):957-967. doi: 10.1016/j.healun.2017.02.016. Epub 2017 Feb 17. PMID: 28302503.

Richter MJ, Tiede SL, Sommer N, Schmidt T, Seeger W, Ghofrani HA, Schermuly R, Gall H. Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension. PLoS One. 2016 Nov 1;11(11):e0165982. doi: 10.1371/journal.pone.0165982. PMID: 27802345; PMCID: PMC5089726.

Veith C, Kraut S, Wilhelm J, Sommer N, Quanz K, Seeger W, Brandes RP, Weissmann N, Schröder K. NADPH oxidase 4 is not involved in hypoxia-induced pulmonary hypertension. Pulm Circ. 2016 Sep;6(3):397-400. doi: 10.1086/687756. PMID: 27683617; PMCID: PMC5019094.

Richter MJ, Sommer N, Schermuly R, Grimminger B, Seeger W, Tello K, Ghofrani HA, Gall H. The prognostic impact of thyroid function in pulmonary hypertension. J Heart Lung Transplant. 2016 Dec;35(12):1427-1434. doi: 10.1016/j.healun.2016.05.022. Epub 2016 Jun 3. PMID: 27373820.

Richter MJ, Milger K, Haase S, Sommer N, Tello K, Seeger W, Mayer E, Wiedenroth CB, Grimminger F, George W, Ghofrani HA, Guth S, Gall H. The Clinical Significance of HbA1c in Operable Chronic Thromboembolic Pulmonary Hypertension. PLoS One. 2016 Mar 31;11(3):e0152580. doi: 10.1371/journal.pone.0152580. PMID: 27031508; PMCID: PMC4816563.

Gall H, Sommer N, Milger K, Richter MJ, Voswinckel R, Bandorski D, Seeger W, Grimminger F, Ghofrani HA. Survival with sildenafil and inhaled iloprost in a cohort with pulmonary hypertension: an observational study. BMC Pulm Med. 2016 Jan 12;16:5. doi: 10.1186/s12890-015-0164-2. PMID: 26753921; PMCID: PMC4709958.

Pak O, Bakr AG, Gierhardt M, Albus J, Strielkov I, Kroschel F, Hoeres T, Hecker M, Ghofrani HA, Seeger W, Weissmann N, Sommer N. Effects of carbon monoxide-releasing molecules on pulmonary vasoreactivity in isolated perfused lungs. J Appl Physiol (1985). 2016 Jan 15;120(2):271-81. doi: 10.1152/japplphysiol.00726.2015. Epub 2015 Nov 19. PMID: 26586910.

Hecker M, Behnk A, Morty RE, Sommer N, Vadász I, Herold S, Seeger W, Mayer K. PPAR-α activation reduced LPS-induced inflammation in alveolar epithelial cells. Exp Lung Res. 2015;41(7):393-403. doi: 10.3109/01902148.2015.1046200. PMID: 26151160.

Milger K, Felix JF, Voswinckel R, Sommer N, Franco OH, Grimminger F, Reichenberger F, Seeger W, Ghofrani HA, Gall H. Sildenafil versus nitric oxide for acute vasodilator testing in pulmonary arterial hypertension. Pulm Circ. 2015 Jun;5(2):305-12. doi: 10.1086/680355. PMID: 26064455; PMCID: PMC4449241.

Hecker M, Sommer N, Mayer K. Assessment of short- and medium-chain fatty acids on mitochondrial function in severe inflammation. Methods Mol Biol. 2015;1265:389-96. doi: 10.1007/978-1-4939-2288-8_28. PMID: 25634290.

Sommer N, Grimminger J, Ghofrani HA, Tiede H. Interaction of ambrisentan and phenprocoumon in patients with pulmonary hypertension. Pulm Pharmacol Ther. 2014 Jun;28(1):87-89. doi: 10.1016/j.pupt.2014.03.002. Epub 2014 Mar 18. PMID: 24650719.

Tiede H, Sommer N, Milger K, Voswinckel R, Bandorski D, Schermuly RT, Weissmann N, Grimminger F, Seeger W, Ghofrani HA. Short-term improvement in pulmonary hemodynamics is strongly predictive of long-term survival in patients with pulmonary arterial hypertension. Pulm Circ. 2013 Sep;3(3):523-32. doi: 10.1086/674338. Epub 2013 Nov 19. PMID: 24618538; PMCID: PMC4070816.

Veit F, Pak O, Egemnazarov B, Roth M, Kosanovic D, Seimetz M, Sommer N, Ghofrani HA, Seeger W, Grimminger F, Brandes RP, Schermuly RT, Weissmann N. Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling. Antioxid Redox Signal. 2013 Dec 20;19(18):2213-31. doi: 10.1089/ars.2012.4904. Epub 2013 Jul 20. PMID: 23706097.

Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty RE, Seeger W, Mayer K. Impact of short- and medium-chain fatty acids on mitochondrial function in severe inflammation. JPEN J Parenter Enteral Nutr. 2014 Jul;38(5):587-94. doi: 10.1177/0148607113489833. Epub 2013 May 23. PMID: 23703093.

Pak O*, Sommer N*, Hoeres T, Bakr A, Waisbrod S, Sydykov A, Haag D, Esfandiary A, Kojonazarov B, Veit F, Fuchs B, Weisel FC, Hecker M, Schermuly RT, Grimminger F, Ghofrani HA, Seeger W, Weissmann N. Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model. Am J Respir Cell Mol Biol. 2013 Sep;49(3):358-67. doi: 10.1165/rcmb.2012-0361OC. PMID: 23590303. *equal contribution.

Ketabchi F, Ghofrani HA, Schermuly RT, Seeger W, Grimminger F, Egemnazarov B, Shid-Moosavi SM, Dehghani GA, Weissmann N, Sommer N. Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction. Respir Res. 2012 Jan 31;13(1):7. doi: 10.1186/1465-9921-13-7. PMID: 22292558; PMCID: PMC3306743.

Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N. Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing. Eur Respir J. 2010 Nov;36(5):1056-66. doi: 10.1183/09031936.00013809. Epub 2010 Jun 1. PMID: 20516051.

Roth M, Rupp M, Hofmann S, Mittal M, Fuchs B, Sommer N, Parajuli N, Quanz K, Schubert D, Dony E, Schermuly RT, Ghofrani HA, Sausbier U, Rutschmann K, Wilhelm S, Seeger W, Ruth P, Grimminger F, Sausbier M, Weissmann N. Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia. Am J Respir Crit Care Med. 2009 Aug 15;180(4):353-64. doi: 10.1164/rccm.200806-848OC. Epub 2009 Jun 4. PMID: 19498059.

Reviews/Editorials/Letters

Sommer, N., H. A. Ghofrani, O. Pak, S. Bonnet, S. Provencher, O. Sitbon, S. Rosenkranz, M. M. Hoeper and D. G. Kiely. "Current and future treatments of pulmonary arterial hypertension." Br J Pharmacol (2021). 178(1): 6-30 DOI: 10.1111/bph.15016. PMID: 32034759

Sommer, N., O. Pak and M. Hecker. "New Avenues for Antiinflammatory Signaling of Nur77 in Acute Lung Injury." Am J Respir Cell Mol Biol (2021). 65(3): 236-237 DOI: 10.1165/rcmb.2021-0210ED. PMID: 34086527

Sommer, N. and R. Schulz. "Mitochondrial Monoamine Oxidase: Another Player in Pulmonary Hypertension?" Am J Respir Cell Mol Biol (2021). 64(3): 277-278 DOI: 10.1165/rcmb.2020-0523ED. PMID: 33321051

Sommer, N., N. Weissmann and H. A. Ghofrani. "Metabolic Reprogramming in Congenital Cyanotic Heart Disease: Another Fight in Puberty?" Circulation (2021). 143(23): 2273-2276 DOI: 10.1161/circulationaha.121.054217. PMID: 34097444

Gierhardt, M., O. Pak, D. Walmrath, W. Seeger, F. Grimminger, H. A. Ghofrani, N. Weissmann, M. Hecker and N. Sommer. "Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome." Eur Respir Rev (2021). 30(161) DOI: 10.1183/16000617.0059-2021. PMID: 34526314

Mamazhakypov, A., N. Sommer, B. Assmus, K. Tello, R. T. Schermuly, D. Kosanovic, A. S. Sarybaev, N. Weissmann and O. Pak. "Novel Therapeutic Targets for the Treatment of Right Ventricular Remodeling: Insights from the Pulmonary Artery Banding Model." Int J Environ Res Public Health (2021). 18(16) DOI: 10.3390/ijerph18168297. PMID: 34444046

Hüttemann M, Sommer N, Weissmann N, Grossman LI. Letter by Hüttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction". Circ Res. 2019 Sep 27;125(8):e33-e34. doi: 10.1161/CIRCRESAHA.119.315815. Epub 2019 Sep 26. PMID: 31557122; PMCID: PMC6764598.

Strielkov I, Krause NC, Sommer N, Schermuly RT, Ghofrani HA, Grimminger F, Gudermann T, Dietrich A, Weissmann N. Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels. Exp Physiol. 2018 Sep;103(9):1185-1191. doi: 10.1113/EP087117. Epub 2018 Jul 6. PMID: 29917290.

Sommer N. Anoctamin-1: A Novel Mitochondrial Ion Channel Regulating Cellular Apoptosis and Proliferation? Am J Respir Cell Mol Biol. 2018 May;58(5):558-559. doi: 10.1165/rcmb.2017-0355ED. PMID: 29714635.

Hecker M, Sommer N, Tello K, Hecker A, Seeger W, Mayer K. Ambulant erworbene Pneumonie [Community-acquired pneumonia]. Med Klin Intensivmed Notfmed. 2018 May;113(4):313-324. German. doi: 10.1007/s00063-018-0426-x. Epub 2018 Apr 10. PMID: 29637219.

Sommer N, Richter MJ, Tello K, Grimminger F, Seeger W, Ghofrani HA, Gall H. Update pulmonalarterielle Hypertonie: Definitionen, Diagnose, Therapie [Update pulmonary arterial hypertension : Definitions, diagnosis, therapy]. Internist (Berl). 2017 Sep;58(9):937-957. German. doi: 10.1007/s00108-017-0301-5. PMID: 28819824.

Pak O, Sydykov A, Kosanovic D, Schermuly RT, Dietrich A, Schröder K, Brandes RP, Gudermann T, Sommer N, Weissmann N. Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species. Adv Exp Med Biol. 2017;967:195-225. doi: 10.1007/978-3-319-63245-2_12. PMID: 29047088.

Strielkov I, Pak O, Sommer N, Weissmann N. Recent advances in oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. J Appl Physiol (1985). 2017 Dec 1;123(6):1647-1656. doi: 10.1152/japplphysiol.00103.2017. Epub 2017 Jul 27. PMID: 28751366.

Grimminger J, Richter M, Tello K, Sommer N, Gall H, Ghofrani HA. Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension. Can Respir J. 2017;2017:8381653. doi: 10.1155/2017/8381653. Epub 2017 Mar 27. PMID: 28522921; PMCID: PMC5385916.

Hecker M, Sommer N, Hecker A, Bandorski D, Weigand MA, Krombach GA, Mayer E, Walmrath D. Lungenembolie [Pulmonary embolism]. Anaesthesist. 2017 Mar;66(3):211-226. German. doi: 10.1007/s00101-017-0282-8. PMID: 28204834.

Sommer N, Hecker M, Tello K, Richter M, Liebetrau C, Weigand MA, Seeger W, Ghofrani A, Gall H. Pulmonale Hypertonie : Was ist neu in der Therapie? [Pulmonary hypertension : What is new in therapy?]. Anaesthesist. 2016 Aug;65(8):635-52. German. doi: 10.1007/s00101-016-0207-y. PMID: 27492004.

Sommer N, Strielkov I, Pak O, Weissmann N. Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. Eur Respir J. 2016 Jan;47(1):288-303. doi: 10.1183/13993003.00945-2015. Epub 2015 Oct 22. PMID: 26493804.

Hecker M, Sommer N, Hecker A, Bandorski D, Weigand MA, Krombach GA, Mayer E, Walmrath D. Lungenembolie [Pulmonary embolism]. Med Klin Intensivmed Notfmed. 2016 Mar;111(2):163-75; quiz 176-7. German. doi: 10.1007/s00063-015-0114-z. Epub 2015 Nov 30. PMID: 26621816.

Malczyk M, Veith C, Schermuly RT, Gudermann T, Dietrich A, Sommer N, Weissmann N, Pak O. NADPH oxidases-do they play a role in TRPC regulation under hypoxia? Pflugers Arch. 2016 Jan;468(1):23-41. doi: 10.1007/s00424-015-1731-3. Epub 2015 Oct 1. PMID: 26424109.

Fuchs B, Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Grimminger F, Seeger W, Gudermann T, Weissmann N. Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction. Respir Physiol Neurobiol. 2010 Dec 31;174(3):282-91. doi: 10.1016/j.resp.2010.08.013. Epub 2010 Aug 27. PMID: 20801235.

Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Gudermann T, Schulz R, Seeger W, Grimminger F, Weissmann N. Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. Eur Respir J. 2008 Dec;32(6):1639-51. doi: 10.1183/09031936.00013908. PMID: 19043010.

Weissmann N, Sommer N, Schermuly RT, Ghofrani HA, Seeger W, Grimminger F. Oxygen sensors in hypoxic pulmonary vasoconstriction. Cardiovasc Res. 2006 Sep 1;71(4):620-9. doi:  10.1016/j.cardiores.2006.04.009. PMID: 16765922.