COPD and Emphysema
Original Research
Qi, H., H. Liu, S. S. Pullamsetti, S. Günther, C. Kuenne, A. Atzberger, N. Sommer, S. Hadzic, A. Günther, N. Weissmann, Y. Zhou, X. Yuan and T. Braun. "Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease." Circulation (2021). 144(13): 1042-1058 DOI: 10.1161/circulationaha.120.051680. PMID: 34247492
Gredic, M., C. Y. Wu, S. Hadzic, O. Pak, R. Savai, B. Kojonazarov, S. Doswada, A. Weiss, A. Weigert, A. Guenther, R. P. Brandes, R. T. Schermuly, F. Grimminger, W. Seeger, N. Sommer, S. Kraut and N. Weissmann. "Myeloid cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice." Eur Respir J (2021). DOI: 10.1183/13993003.01153-2021. PMID: 34475225
Seimetz M*, Sommer N*, Bednorz M*, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu CY, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2020 Jun;2(6):532-546. doi: 1038/s42255-020-0215-8. Epub 2020 Jun 8. Erratum in: Nat Metab. 2020 Jul;2(7):648. PMID: 32694733. *equal contribution.
Fysikopoulos A, Seimetz M, Hadzic S, Knoepp F, Wu CY, Malkmus K, Wilhelm J, Pichl A, Bednorz M, Tadele Roxlau E, Ghofrani HA, Sommer N, Gierhardt M, Schermuly RT, Seeger W, Grimminger F, Weissmann N, Kraut S. Amelioration of elastase-induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice. Br J Pharmacol. 2020 Mar 22. doi: 10.1111/bph.15057. Epub ahead of print. PMID: 32201936.
Pichl A*, Sommer N*, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O, Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA, Weissmann N. Riociguat for treatment of pulmonary hypertension in COPD: a translational study. Eur Respir J. 2019 Jun 27;53(6):1802445. doi: 10.1183/13993003.02445-2018. PMID: 30956210. *equal contribution
Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M. Alternative Oxidase Attenuates Cigarette Smoke-induced Lung Dysfunction and Tissue Damage. Am J Respir Cell Mol Biol. 2019 May;60(5):515-522. doi: 10.1165/rcmb.2018-0261OC. PMID: 30339461; PMCID: PMC6503618.