Clinical Research

Original Research

Sommer N, Noack S, Hecker A, Hackstein H, Bein G, Weissmann N, Seeger W, Mayer K, Hecker M. Decreased Thymic Output Contributes to Immune Defects in Septic Patients. J Clin Med. 2020 Aug 20;9(9):E2695. doi: 10.3390/jcm9092695. PMID: 32825352.

Yogeswaran A, Gall H, Tello K, Grünig E, Xanthouli P, Ewert R, Kamp JC, Olsson KM, Wißmüller M, Rosenkranz S, Klose H, Harbaum L, Lange TJ, Opitz CF, Waelde A, Milger K, Sommer N, Seeger W, Ghofrani HA, Richter MJ. Impact of SARS-CoV-2 pandemic on pulmonary hypertension out-patient clinics in Germany: a multi-centre study. Pulm Circ. 2020 Jul 23;10(3):2045894020941682. doi: 10.1177/2045894020941682. PMID: 32754309; PMCID: PMC7378724.

Yogeswaran A, Tello K, Faber M, Sommer N, Kuhnert S, Seeger W, Grimminger F, Ghofrani HA, Richter MJ, Gall H. Risk assessment in severe pulmonary hypertension due to interstitial lung disease. J Heart Lung Transplant. 2020 Oct;39(10):1118-1125. doi: 10.1016/j.healun.2020.06.014. Epub 2020 Jun 25. PMID: 32690230.

Schneck E, Edinger F, Hecker M, Sommer N, Pak O, Weissmann N, Hecker A, Reichert M, Markmann M, Sander M, Koch C. Blood Levels of Free-Circulating Mitochondrial DNA in Septic Shock and Postsurgical Systemic Inflammation and Its Influence on Coagulation: A Secondary Analysis of a Prospective Observational Study. J Clin Med. 2020 Jun 30;9(7):2056. doi: 10.3390/jcm9072056. PMID:32629885; PMCID: PMC7408641.

Yogeswaran A, Richter MJ, Sommer N, Ghofrani HA, Seeger W, Gall H, Tello K. Evaluation of pulmonary hypertension by right heart catheterisation: does timing matter? Eur Respir J. 2020 Sep 3;56(3):1901892. doi: 10.1183/13993003.01892-2019. PMID: 32350102.

Schneck E, Mallek F, Schiederich J, Kramer E, Markmann M, Hecker M, Sommer N, Weissmann N, Pak O, Michel G, Hecker A, Padberg W, Boening A, Sander M, Koch C. Flow Cytometry-Based Quantification of Neutrophil Extracellular Traps Shows an Association with Hypercoagulation in Septic Shock and Hypocoagulation in Postsurgical Systemic Inflammation-A Proof-of-Concept Study. J Clin Med. 2020 Jan 8;9(1):174. doi: 10.3390/jcm9010174. PMID: 31936385; PMCID: PMC7019434.

Richter MJ, Fortuni F, Wiegand MA, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Seeger W, Sommer N, Gall H, Ghio S, Tello K. Association of right atrial conduit phase with right ventricular lusitropic function in pulmonary hypertension. Int J Cardiovasc Imaging. 2020 Apr;36(4):633-642. doi: 10.1007/s10554-019-01763-x. Epub 2020 Jan 8. PMID: 31912453.

Husain-Syed F, Birk HW, Ronco C, Schörmann T, Tello K, Richter MJ, Wilhelm J, Sommer N, Steyerberg E, Bauer P, Walmrath HD, Seeger W, McCullough PA, Gall H, Ghofrani HA. Doppler-Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure. J Am Heart Assoc. 2019 Nov 5;8(21):e013584. doi: 10.1161/JAHA.119.013584. Epub 2019 Oct 19. PMID: 31630601; PMCID: PMC6898799.

Tello K, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Seeger W, Dumitrescu D, Sommer N, Brunst A, Gall H, Richter MJ. Impaired right ventricular lusitropy is associated with ventilatory inefficiency in pulmonary arterial hypertension. Eur Respir J. 2019 Nov 21;54(5):1900342. doi: 10.1183/13993003.00342-2019. PMID: 31515402.

Tello K, Wan J, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Mohajerani E, Seeger W, Herberg U, Sommer N, Gall H, Richter MJ. Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Sep;12(9):e009047. doi: 10.1161/CIRCIMAGING.119.009047. Epub 2019 Sep 10. PMID: 31500448; PMCID: PMC7099862.

Tello K, Ghofrani HA, Heinze C, Krueger K, Naeije R, Raubach C, Seeger W, Sommer N, Gall H, Richter MJ. A simple echocardiographic estimate of right ventricular-arterial coupling to assess severity and outcome in pulmonary hypertension on chronic lung disease. Eur Respir J. 2019 Sep 12;54(3):1802435. doi: 10.1183/13993003.02435-2018. PMID: 31073085.

Pichl A*, Sommer N*, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O, Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA, Weissmann N. Riociguat for treatment of pulmonary hypertension in COPD: a translational study. Eur Respir J. 2019 Jun 27;53(6):1802445. doi: 10.1183/13993003.02445-2018. PMID: 30956210. *equal contribution

Sommer N, Droege F, Gamen KE, Geisthoff U, Gall H, Tello K, Richter MJ, Deubner LM, Schmiedel R, Hecker M, Spiekerkoetter E, Wirsching K, Seeger W, Ghofrani HA, Pullamsetti S. Treatment with low-dose tacrolimus inhibits bleeding complications in a patient with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension. Pulm Circ. 2019 Apr-Jun;9(2):2045894018805406. doi: 10.1177/2045894018805406. Epub 2018 Sep 27. PMID: 30260738; PMCID: PMC6432681.

Gall H, Felix JF, Schneck FK, Milger K, Sommer N, Voswinckel R, Franco OH, Hofman A, Schermuly RT, Weissmann N, Grimminger F, Seeger W, Ghofrani HA. The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups. J Heart Lung Transplant. 2017 Sep;36(9):957-967. doi: 10.1016/j.healun.2017.02.016. Epub 2017 Feb 17. PMID: 28302503.

Richter MJ, Tiede SL, Sommer N, Schmidt T, Seeger W, Ghofrani HA, Schermuly R, Gall H. Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension. PLoS One. 2016 Nov 1;11(11):e0165982. doi: 10.1371/journal.pone.0165982. PMID: 27802345; PMCID: PMC5089726.

Richter MJ, Milger K, Haase S, Sommer N, Tello K, Seeger W, Mayer E, Wiedenroth CB, Grimminger F, George W, Ghofrani HA, Guth S, Gall H. The Clinical Significance of HbA1c in Operable Chronic Thromboembolic Pulmonary Hypertension. PLoS One. 2016 Mar 31;11(3):e0152580. doi: 10.1371/journal.pone.0152580. PMID: 27031508; PMCID: PMC4816563.

Gall H, Sommer N, Milger K, Richter MJ, Voswinckel R, Bandorski D, Seeger W, Grimminger F, Ghofrani HA. Survival with sildenafil and inhaled iloprost in a cohort with pulmonary hypertension: an observational study. BMC Pulm Med. 2016 Jan 12;16:5. doi: 10.1186/s12890-015-0164-2. PMID: 26753921; PMCID: PMC4709958.

Milger K, Felix JF, Voswinckel R, Sommer N, Franco OH, Grimminger F, Reichenberger F, Seeger W, Ghofrani HA, Gall H. Sildenafil versus nitric oxide for acute vasodilator testing in pulmonary arterial hypertension. Pulm Circ. 2015 Jun;5(2):305-12. doi: 10.1086/680355. PMID: 26064455; PMCID: PMC4449241.

Sommer N, Grimminger J, Ghofrani HA, Tiede H. Interaction of ambrisentan and phenprocoumon in patients with pulmonary hypertension. Pulm Pharmacol Ther. 2014 Jun;28(1):87-89. doi: 10.1016/j.pupt.2014.03.002. Epub 2014 Mar 18. PMID: 24650719.

Tiede H, Sommer N, Milger K, Voswinckel R, Bandorski D, Schermuly RT, Weissmann N, Grimminger F, Seeger W, Ghofrani HA. Short-term improvement in pulmonary hemodynamics is strongly predictive of long-term survival in patients with pulmonary arterial hypertension. Pulm Circ. 2013 Sep;3(3):523-32. doi: 10.1086/674338. Epub 2013 Nov 19. PMID: 24618538; PMCID: PMC4070816.

Reviews/Editorials/Letters

Sommer N, Ghofrani HA, Pak O, Bonnet S, Provencher S, Sitbon O, Rosenkranz S, Hoeper MM, Kiely DG. Current and future treatments of pulmonary arterial hypertension. Br J Pharmacol. 2020 Feb 7. doi: 10.1111/bph.15016. Epub ahead of print. PMID: 32034759.

Hecker M, Sommer N, Tello K, Hecker A, Seeger W, Mayer K. Ambulant erworbene Pneumonie [Community-acquired pneumonia]. Med Klin Intensivmed Notfmed. 2018 May;113(4):313-324. German. doi: 10.1007/s00063-018-0426-x. Epub 2018 Apr 10. PMID: 29637219.

Sommer N, Richter MJ, Tello K, Grimminger F, Seeger W, Ghofrani HA, Gall H. Update pulmonalarterielle Hypertonie: Definitionen, Diagnose, Therapie [Update pulmonary arterial hypertension : Definitions, diagnosis, therapy]. Internist (Berl). 2017 Sep;58(9):937-957. German. doi: 10.1007/s00108-017-0301-5. PMID: 28819824.

Grimminger J, Richter M, Tello K, Sommer N, Gall H, Ghofrani HA. Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension. Can Respir J. 2017;2017:8381653. doi: 10.1155/2017/8381653. Epub 2017 Mar 27. PMID: 28522921; PMCID: PMC5385916.

Hecker M, Sommer N, Hecker A, Bandorski D, Weigand MA, Krombach GA, Mayer E, Walmrath D. Lungenembolie [Pulmonary embolism]. Anaesthesist. 2017 Mar;66(3):211-226. German. doi: 10.1007/s00101-017-0282-8. PMID: 28204834.

Sommer N, Hecker M, Tello K, Richter M, Liebetrau C, Weigand MA, Seeger W, Ghofrani A, Gall H. Pulmonale Hypertonie : Was ist neu in der Therapie? [Pulmonary hypertension : What is new in therapy?]. Anaesthesist. 2016 Aug;65(8):635-52. German. doi: 10.1007/s00101-016-0207-y. PMID: 27492004.

Hecker M, Sommer N, Hecker A, Bandorski D, Weigand MA, Krombach GA, Mayer E, Walmrath D. Lungenembolie [Pulmonary embolism]. Med Klin Intensivmed Notfmed. 2016 Mar;111(2):163-75; quiz 176-7. German. doi: 10.1007/s00063-015-0114-z. Epub 2015 Nov 30. PMID: 26621816.