Inhaltspezifische Aktionen

Ausgewählte Publikationen der Arbeitsgruppe "HNO-Tumorforschung Giessen".

 

 

 

 

 

  • Zimmermann PH, Stuut M, Wuerdemann N, Möllenhoff K, Suchan M, Eckel H, Wolber P, Sharma SJ, Kämmerer F, Langer C, Wittekindt C, Wagner S, Kremer B, Speel EJM, Klussmann JP. Upfront Surgery vs. Primary Chemoradiation in an Unselected, Bicentric Patient Cohort with Oropharyngeal Squamous Cell Carcinoma-A Matched-Pair Analysis. Cancers (Basel). 2021 Oct 20;13(21):5265. PMID: 34771428.

  • Meyer MT, Watermann C, Dreyer T, Wagner S, Wittekindt C, Klussmann JP, Ergün S, Baumgart-Vogt E, Karnati S. Differential Expression of Peroxisomal Proteins in Distinct Types of Parotid Gland Tumors. Int J Mol Sci. 2021 Jul 23;22(15):7872. PMID: 34360635.

  • Watermann C, Meyer MT, Valerius KP, Kleefeldt F, Wagner S, Wittekindt C, Klussmann JP, Ergün S, Baumgart-Vogt E, Karnati S. Peroxisomes in the mouse parotid glands: An in-depth morphological and molecular analysis. Ann Anat. 2021 Nov;238:151778. PMID: 34091056.

  • Jaworek C, Verel-Yilmaz Y, Driesch S, Ostgathe S, Cook L, Wagner S, Bartsch DK, Slater EP, Bartsch JW. Cohort Analysis of ADAM8 Expression in the PDAC Tumor Stroma. J Pers Med. 2021 Feb 10;11(2):113. PMID: 33578644.

  • Reder H, Wagner S, Wuerdemann N, Langer C, Sandmann S, Braeuninger A, Dugas M, Gattenloehner S, Wittekindt C, Klussmann JP. Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status. Cancer Med. 2021 Feb;10(4):1347-1356. PMID: 33527763.

  • Wuerdemann N, Pütz K, Eckel H, Jain R, Wittekindt C, Huebbers CU, Sharma SJ, Langer C, Gattenlöhner S, Büttner R, Speel EJ, Suchan M, Wagner S, Quaas A, Klussmann JP. LAG-3, TIM-3 and VISTA Expression on Tumor-Infiltrating Lymphocytes in Oropharyngeal Squamous Cell Carcinoma-Potential Biomarkers for Targeted Therapy Concepts. Int J Mol Sci. 2020 Dec 31;22(1):379. PMID: 33396515.

  • Klein S, Quaas A, Quantius J, Löser H, Meinel J, Peifer M, Wagner S, Gattenlöhner S, Wittekindt C, von Knebel Doeberitz M, Prigge ES, Langer C, Noh KW, Maltseva M, Reinhardt HC, Büttner R, Klussmann JP, Wuerdemann N. Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains. Clin Cancer Res. 2021 Feb 15;27(4):1131-1138. PMID: 33262137.

  • Wuerdemann N, Jain R, Adams A, Speel EM, Wagner S, Joosse SA, Klussmann JP. Cell-Free HPV-DNA as a Biomarker for Oropharyngeal Squamous Cell Carcinoma-A Step Towards Personalized Medicine? Cancers (Basel). 2020 Oct 15;12(10):2997. PMID: 33076524.

  • Kirschberg M, Heuser S, Marcuzzi GP, Hufbauer M, Seeger JM, Đukić A, Tomaić V, Majewski S, Wagner S, Wittekindt C, Würdemann N, Klussmann JP, Quaas A, Kashkar H, Akgül B. ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers. Sci Rep. 2020 Oct 15;10(1):17339. PMID: 33060693.

  • Wagner S, Prigge ES, Wuerdemann N, Reder H, Bushnak A, Sharma SJ, Obermueller T, von Knebel Doeberitz M, Dreyer T, Gattenlöhner S, Wolf G, Pons-Kühnemann J, Wittekindt C, Klussmann JP. Evaluation of p16INK4a expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation. Br J Cancer. 2020 Sep;123(7):1114-1122. PMID: 32624580.

  • Reder H, Taferner VF, Wittekindt C, Bräuninger A, Speel EM, Gattenlöhner S, Wolf G, Klussmann JP, Wuerdemann N, Wagner S. Plasma Cell-Free Human Papillomavirus Oncogene E6 and E7 DNA Predicts Outcome in Oropharyngeal Squamous Cell Carcinoma. J Mol Diagn. 2020 Nov;22(11):1333-1343. PMID: 32822851.

  • Wuerdemann N, Gültekin SE, Pütz K, Wittekindt C, Huebbers CU, Sharma SJ, Eckel H, Schubotz AB, Gattenlöhner S, Büttner R, Speel EJ, Klussmann JP, Wagner S, Quaas A. PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma. Int J Mol Sci. 2020 Jul 23;21(15):5228. PMID: 32718057.

  • Arenz A, Patze J, Kornmann E, Wilhelm J, Ziemann F, Wagner S, Wittig A, Schoetz U, Engenhart-Cabillic R, Dikomey E, Fritz B. HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations. Head Neck. 2019. PMID: 31441163.

  • Grønhøj C, Jensen JS, Wagner S, Dehlendorff C, Friborg J, Andersen E, Wittekindt C, Würdemann N, Sharma SJ, Gattenlöhner S, Klussmann JP, von Buchwald C. Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study. Oncotarget. 2019. PMID: 31384393.

  • Wittekindt C, Wagner S, Bushnak A, Prigge ES, von Knebel Doeberitz M, Würdemann N, Bernhardt K, Pons-Kühnemann J, Maulbecker-Armstrong C, Klussmann JP. Increasing Incidence rates of Oropharyngeal Squamous Cell Carcinoma in Germany and Significance of Disease Burden Attributed to Human Papillomavirus. Cancer Prev Res (Phila). 2019. PMID: 31003993.

  • Reder H, Wagner S, Gamerdinger U, Sandmann S, Wuerdemann N, Braeuninger A, Dugas M, Gattenloehner S, Klussmann JP, Wittekindt C. Genetic alterations in human papillomavirus-associated oropharyngeal squamous cell carcinoma of patients with treatment failure. Oral Oncol. 2019. PMID: 31109697.

  • Schmitt K, Molfenter B, Laureano NK, Tawk B, Bieg M, Hostench XP, Weichenhan D, Ullrich ND, Shang V, Richter D, Stögbauer F, Schroeder L, de Bem Prunes B, Visioli F, Rados PV, Jou A, Plath M, Federspil PA, Thierauf J, Döscher J, Weissinger SE, Hoffmann TK, Wagner S, Wittekindt C, Ishaque N, Eils R, Klussmann JP, Holzinger D, Plass C, Abdollahi A, Freier K, Weichert W, Zaoui K, Hess J. Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer. 2019. PMID: 31135957.

  • Reuschenbach M, Tinhofer I, Wittekindt C, Wagner S, Klussmann JP. A systematic review of the HPV-attributable fraction of oropharyngeal squamous cell carcinomas in Germany. Cancer Med. 2019. PMID: 30821126.

  • Rasmussen JH, Grønhøj C, Håkansson K, Friborg J, Andersen E, Lelkaitis G, Klussmann JP, Wittekindt C, Wagner S, Vogelius IR, von Buchwald C. Risk profiling based on p16 and HPV DNA more accurately predicts location of disease relapse in patients with oropharyngeal squamous cell carcinoma. Ann Oncol. 2019. PMID: 30657857.

  • Tribius S, Würdemann N, Laban S, Sharma SJ, Wagner S, Hoffmann TK, Wittekindt C, Klussmann JP. [Update on HPV-associated head and neck cancer-highlights of the 2018 ASCO Annual Meeting]. HNO. 2018. PMID: 30350217.

  • Wagner S, Reder H, Sharma SJ, Würdemann N, Wittekindt C, Klußmann JP. [HPV-associated oropharyngeal cancer-incidence, trends, diagnosis, and treatment]. Urologe A. 2018. PMID: 30421134.

  • Sharma SJ, Wagner S, Reder HSF, Kroll T, Wuerdemann N, Klussmann JP, Wittekindt C. The 8th edition AJCC/UICC TNM staging for p16-positive oropharyngeal carcinoma: is there space for improvement? Eur Arch Otorhinolaryngol. 2018. PMID: 30327906.

  • Grønhøj C, Jensen DH, Dehlendorff C, Marklund L, Wagner S, Mehanna H, Munck-Wikland E, Ramqvist T, Näsman A, Wittekindt C, Würdemann N, Sharma SJ, Gattenlöhner S, Kiss K, Andersen E, Spruce R, Batis N, Robinson M, Harrington K, Winter S, Jones TM, Klussmann JP, Dalianis T, Friborg J, von Buchwald C. Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams). Br J Cancer. 2018. PMID: 29795309.

  • Wittekindt C, Wagner S, Sharma SJ, Würdemann N, Knuth J, Reder H, Klußmann JP. HPV - A different view on Head and Neck Cancer. Laryngorhinootologie. 2018. PMID: 29905354.

  • Wagner S, Böckmann H, Gattenlöhner S, Klussmann JP, Wittekindt C. The innate immune system in oropharyngeal squamous cell carcinoma : Immune modulation by HPV. HNO. 2018. PMID: 29468275.
  • Wagner S, Wittekindt C, Sharma SJ, Wuerdemann N, Jüttner T, Reuschenbach M, Prigge ES, von Knebel Doeberitz M, Gattenlöhner S, Burkhardt E, Pons-Kühnemann J, Klussmann JP. Reply to 'Comment on 'Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer". Br J Cancer. 2018. PMID: 29360817.
  • Wittekindt C, Wuerdemann N, Gattenlöhner S, Brobeil A, Wierzbicka M, Wagner S, Klußmann JP. The role of high-risk human papillomavirus infections in laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2017. PMID: 28861601
  • Wagner S, Sharma SJ, Wuerdemann N, Knuth J, Reder H, Wittekindt C, Klussmann JP. Human Papillomavirus-Related Head and Neck Cancer. Oncol Res Treat. 2017. PMID: 28521311.
  • Wagner S, Wittekindt C, Sharma SJ, Wuerdemann N, Jüttner T, Reuschenbach M, Prigge ES, von Knebel Doeberitz M, Gattenlöhner S, Burkhardt E, Pons-Kühnemann J, Klussmann JP. Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer. Br J Cancer. 2017. PMID: 28472822.
  • Brakenhoff RH, Wagner S, Klussmann JP. Molecular Patterns and Biology of HPV-Associated HNSCC. Recent Results Cancer Res. 2017. PMID: 27699528.
  • Reuschenbach M, Wagner S, Würdemann N, Sharma SJ, Prigge ES, Sauer M, Wittig A, Wittekindt C, von Knebel Doeberitz M, Klussmann JP. [Human papillomavirus and squamous cell cancer of the head and neck region : Prognostic, therapeutic and prophylactic implications]. HNO. 2016. PMID: 26864190.
  • Watermann C, Valerius KP, Wagner S, Wittekindt C, Klussmann JP, Baumgart-Vogt E, Karnati S. Step-by-step protocol to perfuse and dissect the mouse parotid gland and isolation of high-quality RNA from murine and human parotid tissue. Biotechniques. 2016. PMID: 27071609.
  • Ozretić L, Wagner S, Huebbers CU, Gattenlöhner S, Klussmann JP, Beutner D, Zander T, Buettner R, Quaas A. FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma. Oral Oncol. 2016. PMID: 26778475.
  • Wagner S, Wittekindt C, Reuschenbach M, Hennig B, Thevarajah M, Würdemann N, Prigge ES, von Knebel Doeberitz M, Dreyer T, Gattenlöhner S, Klussmann JP. CD56-positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma. Int J Cancer. 2015. PMID: 26662627.
  • Wagner S, Würdemann N, Hübbers C, Reuschenbach M, Prigge ES, Wichmann G, Hess J, Dietz A, Dürst M, Tinhofer I, von Knebel-Döberitz M, Wittekindt C, Klussmann JP. HPV-associated head and neck cancer: Mutational signature and genomic aberrations. HNO. 2015. PMID: 26507715.
  • Reuschenbach M, Huebbers CU, Prigge ES, Bermejo JL, Kalteis MS, Preuss SF, Seuthe IM, Kolligs J, Speel EJ, Olthof N, Kremer B, Wagner S, Klussmann JP, Vinokurova S, von Knebel Doeberitz M. (2015): Methylation status of HPV16 E2-binding sites classifies subtypes of HPV-associated oropharyngeal cancers. Cancer. 2015. PMID: 25731880.
  • Sharma SJ, Kreisel M, Holler C, Kroll T, Gamerdinger U, Gattenloehner S, Klussmann JP, Wittekindt C. Compound lesion of a basal cell carcinoma and a malignant melanoma: Is there a common genetic origin? Eur Arch Otorhinolaryngol. 2015. PMID: 25297533.
  • Olthof NC, Huebbers CU, Kolligs J, Henfling M, Ramaekers FC, Cornet I, van Lent-Albrechts JA, Stegmann AP, Silling S, Wieland U, Carey TE, Walline HM, Gollin SM, Hoffmann TK, de Winter J, Kremer B, Klussmann JP, Speel EJ. Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines. Int J Cancer. 2015. PMID: 25082736.
  • Prigge ES, Toth C, Dyckhoff G, Wagner S, Müller F, Wittekindt C, Freier K, Plinkert P, Hoffmann J, Vinokurova S, Klussmann JP, Doeberitz MV, Reuschenbach M. p16(INK4a) /Ki-67 co-expression specifically identifies transformed cells in the head and neck region. Int J Cancer. 2015. PMID: 25104331.
  • Prigge ES, Urban K, Stiegler S, Müller M, Kloor M, Mai S, Ottstadt M, Lohr F, Wenz F, Wagner S, Wittekindt C, Klussmann JP, Hampl M, von Knebel Doeberitz M, Reuschenbach M. No evidence of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16(INK4a) status. Hum Pathol. 2014. PMID: 25257576.

  • Meyer MF, Huebbers CU, Siefer OG, Vent J, Engbert I, Eslick GD, Valter M, Klussmann JP, Preuss SF.Prevalence and risk factors for oral human papillomavirus infection in 129 women screened for cervical HPV infection. Oral Oncol. 2014. PMID: 24169586.

  • Mooren JJ, Gültekin SE, Straetmans JM, Haesevoets A, Peutz-Kootstra CJ, Huebbers CU, Dienes HP, Wieland U, Ramaekers FC, Kremer B, Speel EJ, Klussmann JP.P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias. Int J Cancer. 2014. PMID: 24127203.

  • Arenz A, Ziemann F, Mayer C, Wittig A, Dreffke K, Preising S, Wagner S, Klussmann JP, Engenhart-Cabillic R, Wittekindt C. Increased radiosensitivity of HPV-positive head and neck cancer cell lines due to cell cycle dysregulation and induction of apoptosis. Strahlenther Onkol. 2014. PMID: 24715240.
  • Qian X, Wagner S, Ma C, Coordes A, Gekeler J, Klussmann JP, Hummel M, Kaufmann AM, Albers AE. Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma. J Cancer Res Clin Oncol. 2014. PMID: 24770634.
  • Olthof NC, Speel EJ, Kolligs J, Haesevoets A, Henfling M, Ramaekers FC, Preuss SF, Drebber U, Wieland U, Silling S, Lam WL, Vucic EA, Kremer B, Klussmann JP, Huebbers CU. Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression. PLoS One. 2014. PMID: 24586376.
  • Qian X, Wagner S, Ma C, Klussmann JP, Hummel M, Kaufmann AM, Albers AE. ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status. Oncol Rep. 2013. PMID: 23483187.
  • Huebbers CU, Preuss SF, Kolligs J, Vent J, Stenner M, Wieland U, Silling S, Drebber U, Speel EJ, Klussmann JP. Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis. PLoS One. 2013. PubMed PMID: 23437342.
  • Mooren JJ, Kremer B, Claessen SM, Voogd AC, Bot FJ, Klussmann JP, Huebbers CU, Hopman AH, Ramaekers FC, Speel EJ. Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis. Int J Cancer. 2013. PMID: 22987500.

  • Wagner S, Mayer C, Wittekindt C, Klussmann JP. Human papillomavirus (HPV) and head and neck cancer. Hautarzt. 2012. PMID: 22179127.

  • Albers AE, Chen C, Köberle B, Qian X, Klussmann JP, Wollenberg B, Kaufmann AM. Stem cells in squamous head and neck cancer. Crit Rev Oncol Hematol. 2012. PMID: 21511490.

  • Wittekindt C, Wagner S, Mayer CS, Klussmann JP. Basics of tumor development and importance of human papilloma virus (HPV) for head and neck cancer. Laryngorhinootologie. 2012. PMID: 22456913.

  • Klussmann JP, Wagner S, Wittekindt C. Tonsillar Cancer. Monogr Virol. Basel, Karger, 2012, vol 28, pp 79–87

  • Wittekindt C, Wagner S, Klussmann JP. Recurrent Respiratory Papillomatosis Monogr Virol. Basel, Karger, 2012, vol 28, pp 30–37

  • Semrau R, Duerbaum H, Temming S, Huebbers C, Stenner M, Drebber U, Klussmann JP, Müller RP, Preuss SF.Prognostic impact of human papillomavirus status, survivin, and epidermal growth-factor receptor expression on survival in patients treated with radiochemotherapy for very advanced nonresectable oropharyngeal cancer. Head Neck. 2012. PMID: 23042483.

  • Lace MJ, Anson JR, Klussmann JP, Wang DH, Smith EM, Haugen TH, Turek LP. Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers. J Virol. 2011. PMID: 21123375.

  • Stenner M, Demgensky A, Molls C, Hardt A, Luers JC, Grosheva M, Huebbers CU, Klussmann JP. Prognostic value of survivin expression in parotid gland cancer in consideration of different histological subtypes. Eur J Cancer. 2011. PMID: 21397494.

  • Stenner M, Yosef B, Huebbers CU, Preuss SF, Dienes HP, Speel EJ, Odenthal M, Klussmann JP. Nuclear translocation of β-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression? Histopathology. 2011. PMID: 21438909.

  • Wittekindt C, Wagner S, Klussmann JP. HPV-associated head and neck cancer. The basics of molecular and translational research HNO 2011. PMID: 21769577.

  • Klingenberg B, Hafkamp HC, Haesevoets A, Manni JJ, Slootweg PJ, Weissenborn SJ, Klussmann JP, Speel EJ. p16 INK4A overexpression is frequently detected in tumour-free tonsil tissue without association with HPV. Histopathology. 2010. PMID: 20636796.

  • Stenner M, Weinell A, Ponert T, Hardt A, Hahn M, Preuss SF, Guntinas-Lichius O, Klussmann JP. Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer. Histopathology. 2010. PMID: 21083600.

  • Klussmann JP, Mooren JJ, Lehnen M, Claessen SMH, Stenner M, Huebbers CU, Weissenborn SJ, Wedemeyer I, Preuss SF, Straatmans J, Manni JJ, Hopman AHN, Speel EJM. Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications. Clin Cancer Res. 2009. PMID: 19223504.

  • Hafkamp HC, Mooren JJ, Claessen SM, Klingenberg B, Voogd AC, Bot FJ, Klussmann JP, Hopman AH, Manni JJ, Kremer B, Ramaekers FC, Speel EJ. P21(Cip1/WAF1) expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. Mod Pathol. 2009. PMID: 19305381.

  • Melle C, Ernst G, Winkler R, Schimmel B, Klussmann JP, Wittekindt C, Guntinas-Lichius O, von Eggeling F. Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: Identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue. Proteomics. 2009. PMID: 19337991.

  • Beutner D, Klussmann JP, Guntinas-Lichius O. TP53 mutations in head and neck cancer. N Engl J Med. 2008. PMID: 18337610.

  • Preuss SF, Weinell A, Molitor M, Semrau R, Stenner M, Drebber U, Weissenborn SJ, Speel EJM, Wittekindt C, Guntinas-Lichius O, Hoffmannf TK, Eslick GD, Klussmann JP. Nuclear survivin expression is associated with HPV-independent carcinogenesis and is a negative prognostic marker in oropharyngeal squamous cell carcinoma. Br J Cancer 2008. PMID: 18212752.

  • Hoffmann TK, Sonkoly E, Hauser U, Van Lierop A, Whiteside TL, Klussmann JP, Hafner D, Friebe-Hoffmann U, Scheckenbach K, Erjala K, Grénman R, Schipper J, Bier H, Balz V. Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma. Oral Oncol. 2008. PMID: 18487078.

  • Reimers N, Kasper HU, Weissenborn SJ, Stützer H, Preuss SF, Hoffmann TK, Speel EJ, Dienes HP, Pfister HJ, Guntinas-Lichius O, Klussmann JP. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int. J. Cancer 2007. PMID: 17236202.

  • Hoffmann TK, Arsov C, Schirlau K, Bas M, Friebe-Hoffmann U, Klussmann JP, Scheckenbach K, Balz V, Bier H, Whiteside TL. T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx. Int J Cancer 2006. PMID: 16284959.

  • Wittekindt C, Gultekin E, Weissenborn SJ, Dienes HP, Pfister HJ, Klussmann JP. Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival. Adv Otorhinolaryngol 2005. PMID: 15608419.

  • Smith EM, Ritchie JM, Summersgill KF, Klussmann JP, Lee JH, Wang D, Haugen TH, Turek LP. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer 2004. PMID: 14696105.

  • Klussmann JP, Dinh S, Guntinas-Lichius O, Wittekindt C, Weissenborn S, Wieland U, Dienes HP, Hoffmann T, Smith E, Turek L, Speel EJ, Pfister HJ. HPV-associated tonsillar cancer. An update. HNO 2004. PMID: 15004685.

  • Klussmann JP, Gültekin E, Wieland U, Dries V, Eckel HE, Dienes HP, Pfister HJ, Fuchs P. Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol 2003. PMID: 12598309.

  • Ritchie JM, Smith EM, Summersgill K, Hoffman HT, Wang D, Klussmann JP, Turek LP, Haugen TH. Human Papillomavirus Infection as a Prognostic Factor in Carcinomas of the Oral Cavity and Oropharynx. Int J Cancer 2003. PMID: 12569557.

  • Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Eckel HE, Pfister HJ, Fuchs PG. Human papillomavirus-positive tonsillar carcinomas: a different tumor entity? Med Microbiol Immunol 2003. PMID: 12920586.

  • Klussmann JP, Weissenborn S, Wieland U, Dries V, Kolligs J, Jungehuelsing M, Eckel HE, Dienes HP, Pfister HJ, Fuchs P. Prevalence, Distribution And Viral Load Of Human Papillomavirus 16 DNA In Tonsillar Carcinomas. Cancer 2001. PMID: 11753961.

  • Klussmann JP, Weissenborn S, Fuchs PG. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 2001. PMID: 11484707.