Programme
Tuesday, 24 September 2019, 14:00 - Thursday, 26. September 2019, 13:30
24. September 2019
- 24. Sept. 2019
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Tuesday, September 24, 2019
14.00-15.30 Registration 15.30-15.45 Welcome & Opening of the Workshop A. Meinhardt, Workshop Organization W. Weidner, Dean of the Faculty of Medicine, Justus Liebig University Wolf-Bernhard Schill, Founding Member of the Hessian Centre of Reproductive Medicine 15.45-16.30 Opening Keynote Lecture Chair: Kate Loveland and Constanze Maresch (NYRA)
Infertility due to sperm deficiencies
Christophe Arnoult, Grenoble, France 16.30-17.00
Coffee Break & Installation of Posters
17.00-19.00 Presentation of Posters 1st hour even-numbered, 2nd hour odd-numbered posters 19.00
Welcome Reception
25. September 2019
- 25. Sept. 2019
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Wednesday, September 25, 2019
9.00-13.00
Session I: Germ Cells
Chair: Ans van Pelt and Joachim Weitzel
9.00
Spermatogonial stem cell establishment: Lessons learned from humans and mice
Miles Wilkinson, San Diego, USA 9.30
Molecular basis of post-meiotic male germ cell genome programming
Saadi Khochbin, Grenoble, France
10.00
Molecular physiology of sperm ion channels
Polina Lishko, Berkeley, USA
10.30-11.00
Coffee Break
Chair: Stefan Schlatt and Andrej-Nikolai Spiess
11.00 pH regulation in mammalian sperm Grahn E, Kaupp UB and Berger TK (Bonn, Marburg, Germany) 11.15 Unfolded protein response-related proteins are present in human sperm and are activated after oxidative stress induction Santiago J, Silva JV and Fardilha M (Aveiro, Portugal) 11.30 Germ cell-specific loss of a functioning BTB/POZ domain containing transcription factor causes premature male germ cell aging Ehrenberg S, Kosan C, Heinzel T and Godmann M (Jena, Germany) 11.45 Male germ cell damage induces epididymitis in mice Wang F, Liu WH, Chen R and Han DS (Beijing, China) 12.00 Fertility preservation in pre-pubertal boys with cancer: the cryopreservation of immature testicular tissue and the isolation of spermatogonial stem cells to encourage in vitro spermatogenesis in frozen/thawed testicular samples Tang S, Zainal Y, Eisler M, Jones C and Coward K (Oxford, UK) 12.15 Interacting partners of EPPIN (Epididymal protease inhibitor) in mouse spermatozoa Mariani NAP, Raimundo TFR, Andrade AJ, Silva AAS, Andrade AD, Kushima H, Santos LD and Silva EJR (Botucatu, Brasil) 12.30 Optical recording of rapid non-genomic progesterone signaling events in
human spermKierzek M, Miller EW, Strünker T and Brenker C (Münster, Germany) 13.00-14.00
Lunch
14.00-18.00
Session II: Somatic Cells
Chair: Davor Ježek and Katja Teerds
14.00
Testicular organoids to explore stem cell niche, disease and development
João Alves-Lopes, Cambridge, UK 14.30
Development of the human fetal testis - signalling pathways involved and consequences of dysregulation
Anne Jørgensen, Copenhagen, Denmark 15.00
The battle of the sexes: Setting the gonad on the testis pathway
Blanche Capel, Durham, USA 15.30-16.00
Coffee Break
Chair: Maren Godmann and Artur Mayerhofer
16.00 Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis Rotgers E, Cisneros-Montalvo S, Nurmio M and Toppari J (Turku, Finland) 16.15 Finding needles in haystacks – An innovative strategy to identify novel genes causing Sertoli-cell-only syndrome Emich J, Friedrich C, Wöste M, Ruckert C, Kliesch S, Dugas M and
Tüttelmann F (Münster, Germany)16.30 CCDC42 localizes to manchette, HTCA and tail in male germ cells but is a novel centrosomal protein in somatic cells Tapia Contreras C and Hoyer-Fender S (Göttingen, Germany) 16.45 The prorenin receptor is required for spermatogenesis in mice Bagheri-Fam S, Ahmady S, La HM, Bernard P, Hobbs RM, Pask AJ and Wilhelm D (Melbourne, Australia) 17.00 Mast cells in human foetal testis and epididymis: a comparative study Himelreich Peric M, Krsnik D, Jezek D, Goluza T, Katusic Bojanac A and
Kos M (Zagreb, Croatia)17.15 A novel toolkit for cell specific functional in vivo and structural in situ analysis of the mouse testis Fleck D, Uesaka N, Fischoeder J, Kenzler L, Moosmann R, Mundt N, Spehr J and Spehr M (Aachen, Germany) 18.45
Bus departure from conference site
19.30
Workshop Dinner at the "Dammühle", Wehrshausen
26. September 2019
- 26. Sept. 2019
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Thursday, September 26, 2019
9.00-13.30
Session III: Networks
Chair: Sandra Amaral and Nina Neuhaus
9.00
Single cell transcriptomics during sex determination
Serge Nef, Geneva, Switzerland 9.30
EAA Lecture
The "omics" of human male infertility: integrating big data in a systems biology approach
Rafael Oliva, Barcelona, Spain
10.00
New insights into mammalian testis differentiation: A lesson from Frank Lillie´s freemartin
Humphrey Yao, Research Triangle Park, USA
10.30-11.00
Coffee Break
Chair: Jean-Pierre Allam and Daniela Patricio
11.00 Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
Zhang FP, Malinen M, Mehmood A, Lehtiniemi T, Elo LL, Ohlsson C, Kotaja N, Poutanen M, Palvimo JJ and Sipilä P (Turku, Finland)
11.15 Role of occludin in homeostatic regulation of the epididymal microenvironment Liu BY, Zhang BL, Gao DY, Zhang ZP, Xue XB, Li Q, Smith T, Breton S, Zhang YL, Li JS and Shum W (Boston, USA; Shanghai, China)
11.30 Mouse testicular macrophages express transient receptor potential channel type V2 (TRPV2) - a cation channel involved in testicular inflammation in a mouse model for infertility (AROM+) Eubler K, Kaseder M, Missel A, Strauss L, Poutanen M and Mayerhofer A (Turku, Finland; Munich, Germany)
11.45 Characterization of CCR6 and CCL20 in testis and ejaculates from men with chronic genital tract inflammation Duan YG, Yu CF, Yeung WSB, Haidl G and Allam JP (Shenzhen, China; Bonn, Germany)
12.00 Defining the genetic causes of male infertility using flies and humans Cauchi LM, Hartmann K, Houston BJ, Nagirnaja L, Aston KI, Conrad DF, Fietz D, O’Bryan MK and Burke R (Salt Lake City, Beaverton, USA; Melbourne, Australia)
12.15 Testicular bioenergetics and sperm morphology are influenced by caloric restriction in rats Martins AD, Jarak I, Morais T, Carvalho RA, Oliveira PF, Monteiro MP and Alves MG
12.30 HSD17b3 knockout mice serve as a model to define mechanisms behind the altered endocrine phenotype of patients with HSD17b3 mutations Junnila A, Huhtaniemi R, Zhang FP, Strauss L, Kotaja N, Ohlsson C,
Huhtaniemi I, Sipilä P and Poutanen M13.00-14.00
Lunch
14.00-14.45 Closing Keynote Lecture Chair: Raul Sanchez and Florian Wagenlehner (Urology)
Viral infections and innate immunity in the male genital tract
Nathalie Dejucq-Rainsford, Rennes, France
14.45-15.00
Farewell
J. Klug and H.-C. Schuppe
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