Publications

• 2024

Alashkar Alhamwe, B., Ponath, V., Alhamdan, F., ... Stiewe, T., ... & Pogge von Strandmann, E. (2024). BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells. Cell Mol Immunol 21, 918–931.

Alashkar Alhamwe, B.; Yuskaeva, K.; Wulf, F.; Trinkmann, F.; Kriegsmann, M.; Thomas, M.; Keber, C.U.; Pogge von Strandmann, E.; Herth, F.J.; Kolahian, S.; et al. (2024). Peripheral Inflammation Featuring Eosinophilia or Neutrophilia Is Associated with the Survival and Infiltration of Eosinophils within the Tumor among Various Histological Subgroups of Patients with NSCLC. Int. J. Mol. Sci. 25, 9552.

Giaimo, B. D., Friedrich, T., Ferrante, F Bartkuhn, M. & Borggrefe, T. (2024). Comprehensive genomic features indicative for Notch responsiveness. Nucleic Acids Research, Volume 52, Issue 9, Pages 5179–5194.

Ianni, A., Kumari, P., Tarighi, S., Braun, T. & Vaquero, A. (2024). SIRT7: a novel molecular target for personalized cancer treatment?. Oncogene 43, 993–1006.

Turkowski, K., Herzberg, F., Günther, S., … Grimminger, F., Seeger, W., Sültmann, H., Stiewe, T., Pullamsetti, S. S. & Savai, R. (2024). miR-147b mediated suppression of DUSP8 promotes lung cancer progression. Oncogene 43, 1178–1189.

Review:

Arndt P. F., Turkowski, K., Cekay, M. J., Eul, B., Grimminger, F., Savai, R. (2024). Endothelin and the tumor microenvironment: a finger in every pie. Clin Sci (Lond); 138 (11): 617–634.

• 2023

Böğürcü-Seidel, N., Ritschel, N., Acker, T., & Németh, A. (2023). Beyond ribosome biogenesis: noncoding nucleolar RNAs in physiology and tumor biology. Nucleus, 14(1), 2274655.

Karger, A., Mansouri, S., Leisegang, M. S., Weigert, A., Günther, S., Kuenne, C., ... & Savai, R. (2023). ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. The EMBO Journal, 42(18), e111620.

Logotheti, S., Stiewe, T., & Georgakilas, A. G. (2023). The Role of Human Endogenous Retroviruses in Cancer Immunotherapy of the Post-COVID-19 World. Cancers, 15(22), 5321.

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., ... Pogge von Strandmann, E., … & Stiewe, T. (2023). Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis. Journal of Experimental & Clinical Cancer Research, 42(1), 203.

Taylor, J., Uhl, L., Moll, I., Hasan, S. S., Wiedmann, L., Morgenstern, J., ... Borggrefe, T., … & Fischer, A. (2023). Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia. Nature Cancer, 4(11), 1544-1560.

Wu, F., Li, X., Looso, M., Liu, H., Ding, D., Günther, S., ... Weissmann, N., … & Braun, T. (2023). Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. Nature Genetics, 55(1), 100-111.

Zheng, X., Sarode, P., Weigert, A., Turkowski, K., Chelladurai, P., Günther, S., ... Grimminger, F., Stiewe, T., … Pullamsetti, S. S. & Savai, R. (2023). The HDAC2-SP1 axis orchestrates protumor macrophage polarization. Cancer research, 83(14), 2345-2357.

• 2022

Alsina-Sanchis E, …, Borggrefe T, …., Rodriguez-Vita J. (2022). Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages. Cancer Res. 82(23):4414-28.

Friedrich T, …, Stiewe T, …, Borggrefe T. (2022). Notch-dependent and -independent functions of transcription factor RBPJ. Nucleic Acids Res. 50(14):7925-37.

Gagliani EK, …, Borggrefe T, …, Kovall, RA. (2022). A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects. PLoS Genet. 18(8):e1010335.

Hall D, …, Borggrefe T, …, Kovall, RA. (2022). The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3. Nucleic Acids Res. 50(22):13083-99.

Mansouri S, …, Stiewe T, …, Savai R. (2022). Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity. Elife. 11.

Merle N, …, Wanzel M, Braun T, Borggrefe T, Savai R, …, Stiewe T. (2022) Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase. Mol Cancer. 21(1):191.

Weigert A, …, Turkowski K, …, Grimminger F, …, Pullamsetti SS, Savai R. (2022). Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system. Nat Commun. 13(1):6078.

Zhang T, …, Braun T. (2022). Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells. Nat Commun. 13(1):6907.

Review:

Giaimo BD, Borggrefe T. (2022). Enhancer-promoter communication: unraveling enhancer strength and positioning within a given topologically associating domain (TAD). Signal Transduct Target Ther. 7(1):281.

• 2021

Pan L, Hoffmeister P, Turkiewicz A, Huynh N N D, Grosse-Berkenbusch A, Knippschild U, Gebhardt J C M, Baumann B, Borggrefe T and Oswald F. (2021). Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Cancers (Basel) 13.

Timofeev O and Stiewe T. (2021). Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy. Cancers (Basel) 13.