Winter School 2019
Program of the 2019 IRTG winterschool
9th Winter School of the Collaborative Research Centre TRR81
“Chromatin Changes in Differentiation and Malignancies” Marburg-Giessen-Bad Nauheim-Rotterdam
at the Kleinwalsertal, February 24 - March 01, 2019
Sunday 24.2.2019
20:15 Ski Rental
Monday 25.2.2019
MORNING SESSION
09:00-11:30
Chair: Lea Albert and Johan Slotman
Welcome at the seminar room - Sjaak Philipsen
-
Benedetto Daniele Giaimo (PI Borggrefe Gi) Structural and functional studies of the RBPJ/SHARP
complex reveal a conserved corepressor binding site -
Kristel Eigenhuis (PI Van den Berg R) Unravelling NIPBL and Integrator function in cortical
development -
Alina Airich (PI Borggrefe Gi) Cyclin-dependent kinase-6 (CDK6) in the regulation of the Notch
response -
Anne Korporaal (PI Huylebroeck R) Selected studies of Zeb2 locus regulation and Zeb2 partners in
embryonic stem cells -
Caroline Bouchard (PI Bauer M) Genomic location of PRMT6-dependent H3R2 methylation is decisive
for the transcriptional outcome of associated genes
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Macarena Moronta and Tobias Zimmermann
-
Lieke Koornneef (PI Baarends R) The role of HORMAD1 in meiotic DSB repair
-
Markus Seibert (PI Schmitz Gi) CDK1-mediated phosphorylation at H2B serine 6 is required for
mitotic chromosome segregation -
Mariana Pelicano de Almeida (PI Poot R) The role of chromatin modifiers in autism spectrum disorder
-
Johanna Senst (PI Kolb M) Computational search for ligands of PRMT6
-
Kari-Pekka Skarp (PI Galjart R) Dynamic behaviour of CTCF
-
Ikram Ullah (PI Brehm M) Role of RNA in the recruitment of dMi-2
Tuesday 26.2.2019
08:00-09:00 Breakfast
MORNING SESSION
09:00-11:30
Chair: Alina Airich and Christ Leemans
-
Alexandra Piët (PI Fornerod R) The role of SMPD4 in cytokinesis and microcephaly
-
Lisa Weber (PI Liefke M) The role of EPOP in differentiation and reprogramming
-
Macarena Moronto (PI Wendt R) STAG1 or STAG2 – how to specify the functions of the cohesin
complex? -
Sabrina Fischer (PI Liefke M) Molecular mechanisms of the PRC 2 associated factor EPOP
-
Xabier Vergara (PI van Steensel A) Effect of chromatin environment in DNA double strand break
repair -
Alexander Brehm To be or not te be a NuRD
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Teresa Robert and Markus Seibert
-
Esmee van der Ploeg (PI Stadhouders R) Exploring the division of labor between Th2 cells and ILC2s
in type-2 immunity and asthma -
Nadine Übelmesser (PI Papantonis Gö) Mitotic bookmarking in cell cycle progression and disease
-
Johan Slotman (PIs Houtsmuller and Wendt R) Super-resolution microscopy for studying chromatin
organization -
Spyros Palikyras (PI Papantonis Gö) Senescence-induced CTCF clustering via phase separation and
PTMs -
Thijs Verheul (PI Philipsen R) In search of novel γ-globin inducers to treat sickle cell disease and β-
thalassemia -
Debbie van den Berg and Sjaak Philipsen Why should I stay in science?
Wednesday 27.2.2019
Morning SESSION
9:00-11:30
Chair: Sabrina Fischer and Lukas Kuijpers
-
Josep Rullo-Tubau (PI Vázquez M) Peptides as tools for the modulation of NuRD function
-
Jelle Folkerts (PI Stadhouders R) Butyrate inhibits human mast cell activation through regulation of
expression of key signal transducers -
Tobias Zimmermann (PIs Goesmann and Bartkuhn Gi) Combined epigenome and transcriptome
analysis -
Lize Meert (PI Poot R) Protein interaction networks of autism-related chromatin modifiers in human
neural stem cells -
Andreas Herchenröther (PI Hake Gi) Functional analysis of the PRTH complex, a novel member of the
PWWP2A-H2A.Z chromatin axis -
Maarten Fornerod Computational biology of childhood leukemias
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Lize Meert and Andreas Herchenröther
-
Lucas Kuijpers (PIs Mulugeta and Grosveld R) Understanding the dynamics of hematopoietic
differentiation -
Hang Liu (PIs Braun and Yuan BN) Deciphering the role of Suv4-20h1 in heart development and
congenital heart diseases -
Anne van Schoonhoven (PI Stadhouders R) Elucidating the epigenetic landscape of disease-relevant
T-cell states using Hi-ChIP -
Lea Albert (PI Vázquez M) Optochemical Control of MLL1 Activity
-
Teresa Robert-Finestra (PI Gribnau R) The role of the silencing factor SPEN in X chromosome
inactivation -
Esther Sleddens-Linkels (PI Baarends R) In vitro production of oocytes from mouse embryonic stem
cells to study chromosome pairing in meiosis
Thursday 28.2.2019
08:00-09:00 Breakfast
MORNING SESSION
09:00-11:30
Chair: Nadine Übelmesser and Pekka Skarp
-
Michael Staring (PI Huylebroeck and Mulugeta R) BMP-SMAD signalling stabilizes lymphatic
endothelium and valve development by regulating the WNT-β-catenin pathway -
Till Adhikary (PI Chung M) Regulation of IL-12 and IL-10 expression in macrophages
-
Judith Birkhoff (PI Huylebroeck R) Understanding the roles and the regulation of ZEB2 during
development and disease -
Xinyue Guo (PIs Braun and Yuan BN) Inactivation of Suv4-20h1 in muscle stem cells leads to genome
instability and rhabdomyosarcoma formation -
Christ Leemans (PI van Steensel A) Mechanisms of gene regulation in lamina-associated domains
-
Sjaak Philipsen Closing remarks
12:00-16:00 Open Discussions
16:00-17:30 Workshops on Perspectives
17:30-18:30 Farewell Dinner and events:
19:00-20:00 Torch-light procession
20:00-late Farewell party
Friday 1.3.2019