Genetics

Mammalian histone variant networks: important regulators of DNA-based processes

The main goal of our lab is to understand how changes in chromatin structure and composition can affect DNA-based processes, such as gene expression, DNA damage repair, cell cycle progression and genome stability. Our work focuses on the study of specialized variants of mammalian histone proteins that together with DNA form the building blocks of the smallest unit of chromatin, the nucleosome. Besides our work on basic scientific questions, we are interested in understanding how changes in (PTM) pattern and histone variant networks drive or promote disease progression, in particular cancer development.

To achieve our goals, we employ a wide-range of modern genetical, molecular biological, biochemical, cell biological as well as computational techniques.

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