Winter School 2018
Program of the 2018 IRTG Winter School
8th Winter School of the Collaborative Research Centre TRR81
“Chromatin Changes in Differentiation and Malignancies” Marburg-Giessen-Bad Nauheim-Rotterdam
at the Kleinwalsertal, February 25 - March 02, 2018
Sunday 25.2.2018
20:00 Ski Rental
Monday 26.2.2018
MORNING SESSION
09:00-11:30
Chair: Jana Haas and Ruben Schep
Welcome at the seminar room - Sjaak Philipsen
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Bastian Stielow (PI Suske M) MGA, L3MBTL2 and E2F6 determine genomic loading of the non-canonical Polycomb repressive complex PRC1.6
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Judith Birkhoff (PI Huylebroeck R) Transcription factor Zeb2 action mechanisms and regulations in embryonic cell fate decisions
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Aleksandra Turkiewicz (PI Borggrefe GI) Characterization of the RBPJ/SHARP repressor complex
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Giulia Picco (PI Grosveld R) Identification of unknown transcription factors during hematopoiesis development
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Jonathan Lenz (PI Brehm M) U-shaped - a novel dNuRD complex interactor in Drosophila melanogaster
- Macarena Moronta (PI Wendt R) A role in somatic cells for the germ cell-specific cohesion subunit STAG3
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Valentina Casa and Markus Seibert
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Christ Leemans (PI van Steensel A) Mechanisms of gene regulation in lamina-associated domains
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Yanhan Jia (PI Dobreva BN) The role of Lamin B1 in lung cancer migration and metastasis
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Esther Sleddens-Linkels (PI Baarends R) Oocyte production from mouse embryonic stem cells to study meiotic prophase in vitro
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Saleh Ahmed (PI Bauer M) The role of PRMT4 in regulating the activity of E3 SUMO ligase PIAS1
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Iris Verploegh (PI Huylebroeck R) The role of BMP signaling in Glioblastoma Tumor Initiating stem cell-like cells
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Parysatis Sachs (PI Mermoud M) Chromatin remodeling controls the expression of endogenous retroviruses in embryonic stem cells
Tuesday 27.2.2018
08:00-09:00 Breakfast
MORNING SESSION
09:00-11:30
Chair: Jente van Staalduinen and Sara Völkel
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Robert Liefke (PI G) Investigating novel chromatin regulatory mechanisms
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Lucas Kuijpers (PI Grosveld R) Understanding hematopoietic differentiation using novel single cell genomic approaches
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Markus Seibert (PI Schmitz G) Phosphorylation at the novel histone modification site H2B serine 6 is required for mitotic chromosome segregation
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Eva Niggl (PI Poot R) Exploring the interaction network of autism-related chromatin remodeler CHD8
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Benedetto Daniele Giaimo (PI Borggrefe GI) RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1
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Joachim Boers (PI Gribnau R) MeD-seq, a novel method to detect genome wide DNA methylation
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Teresa Robert and Yanhan Jia
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Lieke Koornneef (PIs Baarends and Houtsmuller R) The role of HORMAD1 in meiotic DSB repair
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Hang Liu (PI Braun/Yuan BN) Deciphering the role of Suv4-20h1 in heart development and congenital heart diseases
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Lize Meert (PI Poot R) Protein interaction networks of autism-related chromatin modifiers in human neural stem cells
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Konstantinos Sofiadis (PI Papantonis K) HMGB2 as a rheostat of genomic organization in senescence
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Esmee van der Ploeg (PI Stadhouders, R) Elucidating the molecular basis of human innate lymphoid cell differentiation, activation and suppression
Wednesday 28.2.2018
Morning SESSION
9:00-11:30
Chair: Joachim Boers and Joanna Brühl
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Miguel Martínez Ara (PI Van Steensel A) Characteristics of enhancer-promoter specificity/cooperativity
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Igor Mačinković (PI Brehm M) Characterisation of CoREST complexes in Drosophila
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Jente van Staalduinen (PI Grosveld R) Visualization of the dynamics of transcription in the 3D space of the nucleus
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Krishna Sreenivasan (PI Braun BN) Epigenetic control of programmed cell death during muscle regeneration
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Valentina Casa (PI Wendt R) Regulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element
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Sara Völkel (PI Suske M) An unexpected cofactor function of the transcription factor Sp2
12:00-17:00 Open Discussions
17:30-18:15 Dinner
EVENING SESSION
18:30-21:30
Chair: Judith Birkhoff and Jonathan Lenz
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Anshu Singh (PI Dobreva BN) Role of Rnf20 in lung cancer initiation and progression
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Johan Slotman (PI Houtsmuller R) Cell cycle dependent behavior of the androgen receptor
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Jana Haas (PI Schmitz G) Characterization of HIPK2-mediated chromatin decondensation
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Thomas van Staveren (PI Wendt R) Seeing is believing - Visualizing cohesin-dependent chromatin structures
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Tobias Zimmermann (PIs Bartkuhn/Goesmann G) Bioinformatics of chromatin research using GALAXY
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Teresa Robert-Finestra (PI Gribnau R) The role of the silencing factor SPEN in X chromosome inactivation
Thursday 1.3.2018
08:00-09:00 Breakfast
MORNING SESSION
09:00-11:30
Chair: Lucas Kuijpers and Alexandra Turkiewicz
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Ruben Schep (PI Van Steensel A) Elucidating the effects of chromatin on DNA double strand break repair response
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Sinja Rakow (PI Bauer M) Regulation of c Myb transcription factor activity by arginine methyltransferases PRMT1 and PRMT4
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Mees van der Ent (PI Fornerod R) RNA sequencing reveals an intronic SMPD4 loss-of-function mutations in congenital cortical microcephaly, suggesting a link with sphingosine metabolism
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Joanna Brühl (PI Brehm/Bouazoune M) Identification of potential chromatin remodeling factor drug targets in Acute Myeloid Leukemia
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Ruben Boers (PI Gribnau R) Retrospective analysis of gene expression
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Sjaak Philipsen Closing remarks
12:00-16:00 Open Discussions
16:00-17:30 Workshops on Perspectives
17:30-18:30 Farewell Dinner and events:
19:00-20:00 Torch-light procession
20:00-late Farewell party
Friday 2.3.2018