Bioinformatics
Analysis of genome-wide binding and transcriptome data
This project is dedicated to provide service in the analysis of genome-wide binding and trancriptomics data that will be obtained by the groups of this collaborative research centre.
For ChIP-Seq experiments we will map the sequencing reads to the reference genome and regions enriched for interacting DNA sequences will be determined on a solid statistical basis. Subsequently, we ensure appropriate graphical representation of the identified reads and bound regions in a genome browser.
The extended type of analysis will include feature correlation, motif identification and statistical testing of their validity, genomic signal aggregation over binding sites or other genomic features (TSS, TES, exons, introns etc,) as well as correlation analysis with available transcriptomics data. Furthermore we will take care of your transcriptomics data originating from gene expression arrays. We will provide information on significantly deregulated genes as well as subsequent analysis of GO terms, pathways etc. Finally we aim to integrate both genome-wide binding as well as expression analyses in order unravel the specific transcriptional program controlled by your transcription factor/histone modification of choice!